More than 95% of the 20,000 to 25,000 transcribed human genes undergo alternative RNA
splicing, which increases the diversity of the proteome. Isoforms derived from the same gene …

Purpose: The BIM deletion polymorphism is associated with apoptosis resistance to EGFR
tyrosine kinase inhibitors (EGFR-TKI), such as gefitinib and erlotinib, in non–small cell lung …

Alternative splicing (AS) is a strictly regulated process that generates multiple mRNA
variants from a single gene, thus contributing to proteome diversity. Transcriptome-wide …

Many tyrosine kinase-driven cancers, including chronic myeloid leukemia (CML), are
characterized by high response rates to specific tyrosine kinase inhibitors (TKIs) like …

Understanding resistance mechanisms in cancer is of utmost importance for the discovery of
novel “druggable” targets. Efficient genetic screening, now even more possible with CRISPR …

Achieving early molecular response (EMR) has been shown to be associated with better
event free survival in patients with chronic phase chronic myeloid leukemia (CP-CML) on …

Alternative splicing (AS) has been shown to participate in prostate cancer development and
progression; however, a link between AS and prostate cancer health disparities has been …

Background. Resistance to epidermal growth factor receptor tyrosine kinase inhibitors
(EGFR‐TKIs) is inevitable in EGFR‐mutant non‐small‐cell lung cancer (NSCLC) patients. A …

Dysregulation of mitochondrial function often precedes malignant transformation of
hematopoietic stem cells (HSCs). Mitochondria have a direct role in the maintenance of HSC …

PURPOSE BIM activation is essential for epidermal growth factor receptor (EGFR)-tyrosine
kinase inhibitor (TKI)–triggered apoptosis in EGFR-mutant non–small-cell lung cancer …