A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions
between luminal contents such as the intestinal microbiota, the underlying immune system …

RNA polymerase (Pol) III transcribes small untranslated RNAs such as 5S ribosomal RNA,
transfer RNAs, and U6 small nuclear RNA. Because of the functions of these RNAs, Pol III …

Backgrounds & Aims Increased permeability is implicated in the pathogenesis of intestinal
disease. In vitro and in vivo studies have linked down-regulation of the scaffolding protein …

Background & Aims Three-dimensional organoid culture has fundamentally changed the in
vitro study of intestinal biology enabling novel assays; however, its use is limited because of …

Ribosomes are macromolecular machines that are globally required for the translation of all
proteins in all cells. Ribosome biogenesis, which is essential for cell growth, proliferation …

Abstract RNA polymerase III (Pol III)-related hypomyelinating leukodystrophy (POLR3-HLD),
also known as 4H leukodystrophy, is a severe neurodegenerative disease characterized by …

Maize (Zea mays) kernel size is an important factor determining grain yield; although
numerous genes regulate kernel development, the roles of RNA polymerases in this process …

Kernel size is an important factor determining grain yield. Although a number of genes
affecting kernel development in maize (Zea mays) have been identified by analyzing kernel …

RNA polymerase III (RNAPIII) contains 17 subunits forming 4 functional domains that control
the different stages of RNAPIII transcription and are dedicated to the synthesis of small …

Colorectal cancer is the world's third most common and second deadliest cancer. Intestinal
tumors are characterized by mutations of Apc, leading to Wnt signaling overactivation in …