At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Plasma high density lipoprotein cholesterol (HDL) comprises a heterogeneous family of
lipoprotein species, differing in surface charge, size and lipid and protein compositions …

High-density lipoprotein (HDL) provides a pathway for the passage of lipid peroxides and
lysophospholipids to the liver via hepatic scavenger receptors. Perhaps more importantly …

Prospective population studies in the primary prevention setting have shown that reduced
plasma levels of HDL cholesterol are associated with an increased risk of coronary disease …

HDL has a wide range of functions some of which are independent of its cholesterol content.
Its cargo of apolipoproteins, various proteins and phospholipids contributes most to its …

High‐density lipoprotein (HDL) is one of the major carriers of cholesterol in the blood. It
attracts particular attention because, in contrast with other lipoproteins, many physiological …

Drugs show their pharmacological effects by inhibiting or activating enzymes. Therefore,
enzyme inhibitors have an essential place in the drug design for numerous different sorts of …

Glycation of LDL occurs chiefly because of the nonenzymatic reaction of glucose and its
metabolites with the free amino groups of lysine of which apolipoprotein B is rich. Higher …

The endothelium is a key constituent of the vascular wall, being actively involved in
maintaining the structural integrity and proper functioning of blood vessels. Hyperlipidemia …

Serum paraoxonase 1 (PON1) is a native lactonase capable of promiscuously hydrolyzing a
broad range of substrates, including organophosphates, esters, and carbonates …