A systematic review of multimodal brain age studies: Uncovering a divergence between model accuracy and utility

RJ Jirsaraie, AJ Gorelik, MM Gatavins, DA Engemann… - Patterns, 2023 - cell.com
Brain aging is a complex, multifaceted process that can be challenging to model in ways that
are accurate and clinically useful. One of the most common approaches has been to apply …

BrainAGE, brain health, and mental disorders: A systematic review

J Seitz-Holland, SS Haas, N Penzel… - Neuroscience & …, 2024 - Elsevier
The imaging-based method of brainAGE aims to characterize an individual's vulnerability to
age-related brain changes. The present study systematically reviewed brainAGE findings in …

Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN)

NS McKay, BA Gordon, RC Hornbeck, A Dincer… - Nature …, 2023 - nature.com
Abstract The Dominantly Inherited Alzheimer Network (DIAN) is an international
collaboration studying autosomal dominant Alzheimer disease (ADAD). ADAD arises from …

Brain aerobic glycolysis and resilience in Alzheimer disease

MS Goyal, T Blazey, NV Metcalf… - Proceedings of the …, 2023 - National Acad Sciences
The distribution of brain aerobic glycolysis (AG) in normal young adults correlates spatially
with amyloid-beta (Aβ) deposition in individuals with symptomatic and preclinical Alzheimer …

Investigating brain aging trajectory deviations in different brain regions of individuals with schizophrenia using multimodal magnetic resonance imaging and brain-age …

JD Zhu, YF Wu, SJ Tsai, CP Lin, AC Yang - Translational Psychiatry, 2023 - nature.com
Although many studies on brain-age prediction in patients with schizophrenia have been
reported recently, none has predicted brain age based on different neuroimaging modalities …

Brain age prediction using the graph neural network based on resting-state functional MRI in Alzheimer's disease

J Gao, J Liu, Y Xu, D Peng, Z Wang - Frontiers in Neuroscience, 2023 - frontiersin.org
Introduction Alzheimer's disease (AD) is a neurodegenerative disease that significantly
impacts the quality of life of patients and their families. Neuroimaging-driven brain age …

Neuroimaging-based brain age estimation: A promising personalized biomarker in neuropsychiatry

D Sone, I Beheshti - Journal of Personalized Medicine, 2022 - mdpi.com
It is now possible to estimate an individual's brain age via brain scans and machine-learning
models. This validated technique has opened up new avenues for addressing clinical …

Predicting aging trajectories of decline in brain volume, cortical thickness and fractional anisotropy in schizophrenia

JD Zhu, SJ Tsai, CP Lin, YJ Lee, AC Yang - Schizophrenia, 2023 - nature.com
Brain-age prediction is a novel approach to assessing deviated brain aging trajectories in
different diseases. However, most studies have used an average brain age gap (BAG) of …

Latent similarity identifies important functional connections for phenotype prediction

A Orlichenko, G Qu, G Zhang, B Patel… - IEEE Transactions …, 2022 - ieeexplore.ieee.org
Objective: Endophenotypes such as brain age and fluid intelligence are important
biomarkers of disease status. However, brain imaging studies to identify these biomarkers …

Accelerated functional brain aging in major depressive disorder: evidence from a large scale fMRI analysis of Chinese participants

Y Luo, W Chen, J Qiu, T Jia - Translational Psychiatry, 2022 - nature.com
Major depressive disorder (MDD) is one of the most common mental health conditions that
has been intensively investigated for its association with brain atrophy and mortality. Recent …