The appearance and growth of malignant tumors is a complicated process that is regulated
by a number of genes. In recent years, studies have revealed that the transforming growth …

Cancer immunotherapy using monoclonal antibodies targeting immune checkpoints has
undoubtedly revolutionized the cancer treatment landscape in the last decade. Immune …

Background Bintrafusp alfa is a first-in-class bifunctional fusion protein composed of the
extracellular domain of transforming growth factor (TGF)-βRII (a TGF-β 'trap') fused to a …

Background We report the clinical activity and safety of bintrafusp alfa, a first-in-class
bifunctional fusion protein composed of the extracellular domain of the transforming growth …

Purpose: Patients with recurrent or metastatic cervical cancer have limited treatment options
after platinum-containing treatment. We initiated a phase I study to assess SHR-1701, a …

Myeloid-derived suppressor cells (MDSCs) and tumor associated macrophages (TAMs) play
key roles in the tumor immune suppressive network and tumor progression. However …

Background High-risk human papilloma viruses (HPV) are a causative agent of anogenital
and oropharyngeal cancers. Patients treated for a preinvasive or invasive HPV-associated …

Background People living with HIV (PLHIV) are at a high risk of developing HPV-related
cancers. HPV-related malignancies occur frequently and/or are high among PLHIV, with …

Precision medicine based upon molecular testing is heralded as a revolution in how cancer
is prevented, diagnosed, and treated. Large efforts across the world aim to conduct …

Background Recurrent respiratory papillomatosis (RRP) is a human papillomavirus (HPV)-
driven disorder that causes substantial morbidity and can lead to fatal distal airway …