T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Cytotoxic T cells are important effectors of anti-tumor immunity. While tumor killing is
ascribed to CD8+ T cell function, pre-clinical and clinical studies have identified intra …

T cell immunity is central for the control of viral infections. To characterize T cell immunity,
but also for the development of vaccines, identification of exact viral T cell epitopes is …

In 1986, Mosmann and Coffman identified 2 functionally distinct subsets of activated CD4 T
cells, Th1 and Th2 cells, being key in distinct T cell mediated responses. Over the past three …

Long-term immunological memory to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is crucial for the development of population-level immunity, which is the aim …

Following antigen encounter and subsequent resolution of the immune response, a single
naïve T cell is able to generate multiple subsets of memory T cells with different phenotypic …

Scholarly and comprehensive yet accessible, this state-of-the-science work is widely
regarded as the definitive graduate-level psychology of religion text. The authors synthesize …

Despite complete or near‐complete suppression of human immunodeficiency virus (HIV)
replication with combination antiretroviral therapy, both HIV and chronic …

CD4 T cells with cytotoxic function were once thought to be an artifact due to long-term in
vitro cultures but have in more recent years become accepted and reported in the literature …

Despite numerous attempts over many years to develop an HIV vaccine based on classical
strategies, none has convincingly succeeded to date. A number of approaches are being …