Privileged structures have been widely used as an effective template in medicinal chemistry
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …

Abstract Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold remained a fascination
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …

Named as the guardian of the genome, p53 is a tumor suppressor that regulates cell
function, often through many different mechanisms such as DNA repair, apoptosis, cell cycle …

Chalcones are a class of privileged scaffolds with high medicinal significance due to the
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …

The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …

Boron containing compounds have not been widely studied in Medicinal Chemistry, mainly
due to the idea that this group could confer some toxicity. Nowadays, this concept has been …

Proteases form one of the largest and more important groups of enzymes. They selectively
catalyze the hydrolysis of peptide bonds and can be divided into four major classes …

A series of chalcone linked-1, 2, 3-triazoles was synthesized via cellulose supported copper
nanoparticle catalyzed click reaction in water. The structures of all the compounds were …

A series of novel chalcones and bis-chalcones containing boronic acid moieties has been
synthesized and evaluated for antitumor activity against the human breast cancer MDA-MB …

In 2003, bortezomib, a first-in-class therapeutic, gained approval from the US Federal Drug
Administration for the treatment of relapsed multiple myeloma and mantle cell lymphoma …