Implications of peptide assemblies in amyloid diseases
Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …
quality of life of millions worldwide, with profound social and economic implications. Despite …
Imaging calcium in neurons
C Grienberger, A Konnerth - Neuron, 2012 - cell.com
Calcium ions generate versatile intracellular signals that control key functions in all types of
neurons. Imaging calcium in neurons is particularly important because calcium signals exert …
neurons. Imaging calcium in neurons is particularly important because calcium signals exert …
High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes
J Schwenk, N Harmel, A Brechet, G Zolles, H Berkefeld… - Neuron, 2012 - cell.com
AMPA-type glutamate receptors (AMPARs) are responsible for a variety of processes in the
mammalian brain including fast excitatory neurotransmission, postsynaptic plasticity, or …
mammalian brain including fast excitatory neurotransmission, postsynaptic plasticity, or …
Active properties of neocortical pyramidal neuron dendrites
Dendrites are the main recipients of synaptic inputs and are important sites that determine
neurons' input-output functions. This review focuses on thin neocortical dendrites, which …
neurons' input-output functions. This review focuses on thin neocortical dendrites, which …
Calcium signaling and amyloid toxicity in Alzheimer disease
Intracellular Ca 2+ signaling is fundamental to neuronal physiology and viability. Because of
its ubiquitous roles, disruptions in Ca 2+ homeostasis are implicated in diverse disease …
its ubiquitous roles, disruptions in Ca 2+ homeostasis are implicated in diverse disease …
Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo
During development there is an activity-dependent switch in synaptic N-Methyl-D-aspartate
(NMDA) receptor subunit composition from predominantly GluN2B to GluN2A, though the …
(NMDA) receptor subunit composition from predominantly GluN2B to GluN2A, though the …
Spine-neck geometry determines NMDA receptor-dependent Ca2+ signaling in dendrites
J Noguchi, M Matsuzaki, GCR Ellis-Davies, H Kasai - Neuron, 2005 - cell.com
Increases in cytosolic Ca 2+ concentration ([Ca 2+] i) mediated by NMDA-sensitive
glutamate receptors (NMDARs) are important for synaptic plasticity. We studied a wide …
glutamate receptors (NMDARs) are important for synaptic plasticity. We studied a wide …
Protein kinase A regulates calcium permeability of NMDA receptors
Abstract Calcium (Ca2+) influx through NMDA receptors (NMDARs) is essential for
synaptogenesis, experience-dependent synaptic remodeling and plasticity. The NMDAR …
synaptogenesis, experience-dependent synaptic remodeling and plasticity. The NMDAR …
Ataxia and altered dendritic calcium signaling in mice carrying a targeted null mutation of the calbindin D28k gene
MS Airaksinen, J Eilers, O Garaschuk… - Proceedings of the …, 1997 - National Acad Sciences
Intracellular calcium-binding proteins are abundantly expressed in many neuronal
populations. Previous evidence suggests that calcium-binding proteins can modulate …
populations. Previous evidence suggests that calcium-binding proteins can modulate …
NMDA receptor subunit-dependent [Ca2+] signaling in individual hippocampal dendritic spines
Ca2+ influx through synaptic NMDA receptors (NMDA-Rs) triggers a variety of adaptive
cellular processes. To probe NMDA-R-mediated [Ca2+] signaling, we used two-photon …
cellular processes. To probe NMDA-R-mediated [Ca2+] signaling, we used two-photon …