Nitrogen containing heterocycles as anticancer agents: a medicinal chemistry perspective

A Kumar, AK Singh, H Singh, V Vijayan, D Kumar… - Pharmaceuticals, 2023 - mdpi.com
Cancer is one of the major healthcare challenges across the globe. Several anticancer
drugs are available on the market but they either lack specificity or have poor safety, severe …

Carbazole scaffolds in cancer therapy: a review from 2012 to 2018

S Issa, A Prandina, N Bedel, P Rongved… - Journal of enzyme …, 2019 - Taylor & Francis
For over half a century, the carbazole skeleton has been the key structural motif of many
biologically active compounds including natural and synthetic products. Carbazoles have …

Synthesis and pharmacological properties of polysubstituted 2-amino-4H-pyran-3-carbonitrile derivatives

Z Tashrifi, M Mohammadi-Khanaposhtani… - Molecular Diversity, 2020 - Springer
Amino-3-cyano-4 H-chromenes are structural core motifs that received increasing attention
in the last years due to their interesting potential pharmacological properties. In this review …

In vitro anticancer activity of methyl caffeate isolated from Solanum torvum Swartz. fruit

C Balachandran, N Emi, Y Arun, Y Yamamoto… - Chemico-biological …, 2015 - Elsevier
The present study was undertaken to investigate the anticancer activity of methyl caffeate
isolated from Solanum torvum Swartz. fruit and to explore the molecular mechanisms of …

Synthesis and biological evaluation of chalcone-linked pyrazolo [1, 5-a] pyrimidines as potential anticancer agents

C Bagul, GK Rao, VKK Makani, JR Tamboli… - …, 2017 - pubs.rsc.org
A series of pyrazolo [1, 5-a] pyrimidines substituted at C5 with 1-phenylprop-2-en-1-one (6a–
q) and 3-phenylprop-2-en-1-one (7a–k) was synthesized and evaluated for antiproliferative …

Click chemistry based multicomponent approach in the synthesis of spirochromenocarbazole tethered 1, 2, 3-triazoles as potential anticancer agents

PV Chavan, UV Desai, PP Wadgaonkar, SR Tapase… - Bioorganic …, 2019 - Elsevier
A series of spirochromenocarbazole tethered 1, 2, 3-triazoles were synthesized via click
chemistry based one-pot, five component reaction between N-propargyl isatins …

Problem Solving and Environmentally Benign Approach toward Diversity Oriented Synthesis of Novel 2-Amino-3-phenyl (or Alkyl) Sulfonyl-4H-chromenes at Ambient …

KS Pandit, RV Kupwade, PV Chavan… - ACS Sustainable …, 2016 - ACS Publications
A problem solving, environmentally benign, and diversity oriented protocol has been
described for multicomponent synthesis of medicinally privileged 2-amino-3-phenyl (or …

Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and …

OPS Patel, A Arun, PK Singh, D Saini… - European journal of …, 2019 - Elsevier
A series of new pyranocarbazole derivatives were synthesized via semi-synthetic
modification of koenimbine (1a) and koenidine (1b) isolated from the leaves of Murraya …

Palladium‐Catalyzed Synthesis of Carbazoles by Perester

L He, Y Xu - Advanced Synthesis & Catalysis, 2022 - Wiley Online Library
An intramolecular C− H amination for the synthesis of carbazoles with a Pd (II)/TBPB system
has been developed. This catalytic amination process forms the carbazole products in good …

Transition-metal-free and organic solvent-free conversion of N-substituted 2-aminobiaryls into corresponding carbazoles via intramolecular oxidative radical …

P Natarajan, D Chuskit - Green chemistry, 2017 - pubs.rsc.org
An atom-economical and environmentally benign approach for the synthesis of N-
substituted carbazoles from analogous 2-aminobiaryls using peroxodisulfate in water is …