The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

Heart failure with preserved ejection fraction (HFpEF), a common condition with an
increased mortality, is strongly associated with obesity and the metabolic syndrome. The …

Proximal tubular epithelial cells (PTEC) in the S1 segment of the kidney abundantly express
sodium-glucose co-transporters (SGLT) that play a critical role in whole body glucose …

Abstract Aims: Angiotensin II (AngII), a vasoconstrictive peptide of the renin–angiotensin
system (RAS), promotes hepatic fibrogenesis and induces microRNA-21 (mir-21) …

Cardiac fibrosis is a critical pathophysiological process that occurs with diverse types of
cardiac injury. Lipids are the most important bioenergy substrates for maintaining optimal …

Food quality and nutritional habits strongly influence human health status. Extensive
research has been conducted to confirm that foods rich in biologically active nutrients have a …

Matrix metalloproteinases (MMPs) are a family of zinc dependent endopeptidases whose
main function is to degrade and deposit structural proteins within the extracellular matrix …

Cardiac fibroblasts (CF) not only modulate extracellular matrix (ECM) proteins homeostasis,
but also respond to chemical and mechanical signals. CF express a variety of receptors …

Current knowledge on the renin–angiotensin system (RAS) indicates its central role in the
pathogenesis of cardiovascular remodelling via both hemodynamic alterations and direct …

MicroRNAs (miRNAs) are small non-coding RNA molecules that diversely regulate
physiological and pathophysiological processes by specifically binding to different regions …