In order to understand the pathophysiology of temporal lobe epilepsy (TLE), and thus to
develop new pharmacological treatments, in vivo animal models that present features …

Surgical removal of the epileptogenic zone provides an effective therapy for several focal
epileptic syndromes. This surgery offers the opportunity to study pathological activity in living …

Single-unit recordings performed in temporal lobe epilepsy patients and in models of
temporal lobe seizures have shown that interneurons are active at focal seizure onset. We …

Human hypothalamic hamartoma (HH) is a rare developmental malformation often
characterized by gelastic seizures, which are refractory to medical therapy. Ictal EEG …

The human brain has been deemed the most complex organ and has captivated
neuroscientists for decades. Most studies of this organ have relied on reductionist model …

Objective. It has been shown that low-intensity ultrasound (LIUS) can suppress seizures in
some laboratory studies. However, the mechanism of the suppression effect of LIUS remains …

Interictal epileptiform discharges (IEDs), occurring in the electroencephalograms (EEG) of
patients with focal epilepsy, are crucial for diagnosis, while their relationship with seizure …

Patients with epilepsy are prone to cognitive decline, depression, anxiety and other
behavioral disorders. Cognitive comorbidities are particularly common and well …

Objective We introduce a novel animal model of somatosensory stimulation-induced reflex
seizures which generates focal seizures without causing damage to the brain. Methods …

In this study, we investigated the relative efficacy of different classes of commonly used anti-
epileptic drugs (AEDs) with different mechanisms of action, individually and in combination …