Challenges and recent progress in oral drug delivery systems for biopharmaceuticals

B Homayun, X Lin, HJ Choi - Pharmaceutics, 2019 - mdpi.com
Routes of drug administration and the corresponding physicochemical characteristics of a
given route play significant roles in therapeutic efficacy and short term/long term biological …

The effects of different dietary fiber pectin structures on the gastrointestinal immune barrier: impact via gut microbiota and direct effects on immune cells

M Beukema, MM Faas, P de Vos - Experimental & Molecular Medicine, 2020 - nature.com
Pectins are dietary fibers with different structural characteristics. Specific pectin structures
can influence the gastrointestinal immune barrier by directly interacting with immune cells or …

[HTML][HTML] Physicochemical properties of mucus and their impact on transmucosal drug delivery

J Leal, HDC Smyth, D Ghosh - International journal of pharmaceutics, 2017 - Elsevier
Mucus is a selective barrier to particles and molecules, preventing penetration to the
epithelial surface of mucosal tissues. Significant advances in transmucosal drug delivery …

Probiotics and the gut immune system: indirect regulation

G La Fata, P Weber, MH Mohajeri - Probiotics and antimicrobial proteins, 2018 - Springer
The gastrointestinal tract (GIT) represents the largest interface between the human organism
and the external environment. In the lumen and upper part of the mucus layer, this organ …

An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across intestinal barriers

Y Xu, N Shrestha, V Préat, A Beloqui - Advanced Drug Delivery Reviews, 2021 - Elsevier
Oral administration is the most commonly used route for drug delivery owing to its cost-
effectiveness, ease of administration, and high patient compliance. However, the absorption …

Potential role of important nutraceuticals in poultry performance and health-A comprehensive review

M Alagawany, SS Elnesr, MR Farag… - Research in veterinary …, 2021 - Elsevier
Antibiotics use in poultry as a growth promoter leads to the propagation of antibiotic-resistant
microorganisms and incorporation of drug residues in foods; therefore, it has been restricted …

Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers

LM Ensign, R Cone, J Hanes - Advanced drug delivery reviews, 2012 - Elsevier
Oral delivery is the most common method for drug administration. However, poor solubility,
stability, and bioavailability of many drugs make achieving therapeutic levels via the …

Polymeric micelles, a promising drug delivery system to enhance bioavailability of poorly water‐soluble drugs

W Xu, P Ling, T Zhang - Journal of drug delivery, 2013 - Wiley Online Library
Oral administration is the most commonly used and readily accepted form of drug delivery;
however, it is find that many drugs are difficult to attain enough bioavailability when …

The Impact of Fusarium Mycotoxins on Human and Animal Host Susceptibility to Infectious Diseases

G Antonissen, A Martel, F Pasmans, R Ducatelle… - Toxins, 2014 - mdpi.com
Contamination of food and feed with mycotoxins is a worldwide problem. At present, acute
mycotoxicosis caused by high doses is rare in humans and animals. Ingestion of low to …

Progress in the design and development of “fast-dissolving” electrospun nanofibers based drug delivery systems-A systematic review

B Balusamy, A Celebioglu, A Senthamizhan… - Journal of Controlled …, 2020 - Elsevier
Electrospinning has emerged as most viable approach for the fabrication of nanofibers with
several beneficial features that are essential to various applications ranging from …