Rheumatoid arthritis: extra-articular manifestations and comorbidities

FA Figus, M Piga, I Azzolin, R McConnell… - Autoimmunity reviews, 2021 - Elsevier
Although synovitis is the pathological hallmark of rheumatoid arthritis (RA), many extra-
articular manifestations (EMs) and comorbidities likely occur due to the complex, chronic …

Cardiovascular comorbidity in rheumatic diseases

MT Nurmohamed, M Heslinga, GD Kitas - Nature Reviews …, 2015 - nature.com
Patients with rheumatoid arthritis (RA) and other inflammatory joint diseases (IJDs) have an
increased risk of premature death compared with the general population, mainly because of …

EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis

MJL Peters, DPM Symmons, D McCarey… - Annals of the …, 2010 - ard.bmj.com
Objectives: To develop evidence-based EULAR recommendations for cardiovascular (CV)
risk management in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and …

Explaining how “high-grade” systemic inflammation accelerates vascular risk in rheumatoid arthritis

N Sattar, DW McCarey, H Capell, IB McInnes - Circulation, 2003 - Am Heart Assoc
There is intense interest in mechanisms whereby low-grade inflammation could interact with
conventional and novel vascular risk factors to promote the atheromatous lesion. Patients …

C-reactive protein is associated with arterial stiffness in apparently healthy individuals

Yasmin, CM McEniery, S Wallace… - … , and vascular biology, 2004 - Am Heart Assoc
Objective—C-reactive protein (CRP) levels predict outcome in healthy individuals and
patients with atherosclerosis. Arterial stiffness also independently predicts all-cause and …

Rheumatoid arthritis is associated with increased aortic pulse-wave velocity, which is reduced by anti–tumor necrosis factor-α therapy

KM Mäki-Petäjä, FC Hall, AD Booth… - Circulation, 2006 - Am Heart Assoc
Background—Rheumatoid arthritis (RA) is associated with increased cardiovascular risk,
which is not explained by traditional cardiovascular risk factors but may be due in part to …

Hypertension in rheumatoid arthritis

VF Panoulas, GS Metsios, AV Pace, H John… - …, 2008 - academic.oup.com
RA associates with an increased burden of cardiovascular disease, which is at least partially
attributed to classical risk factors such as hypertension (HT) and dyslipidaemia. HT is highly …

Association of higher rheumatoid arthritis disease activity during pregnancy with lower birth weight: results of a national prospective study

YA de Man, JMW Hazes… - … : Official Journal of …, 2009 - Wiley Online Library
Objective To determine the outcome of pregnancy in women with rheumatoid arthritis (RA) in
relation to disease activity and medication use during the pregnancy. Methods In a …

Arterial stiffness in chronic inflammatory diseases

MJ Roman, RB Devereux, JE Schwartz… - …, 2005 - Am Heart Assoc
Chronic inflammatory diseases are associated with premature atherosclerosis; however, it is
unknown whether arterial stiffness is increased in this setting, possibly as a manifestation of …

Common inflammatory mediators orchestrate pathophysiological processes in rheumatoid arthritis and atherosclerosis

F Montecucco, F Mach - Rheumatology, 2009 - academic.oup.com
RA is characterized by a systemic inflammatory state, in which immune cells and soluble
mediators play a crucial role. These inflammatory processes resemble those in other chronic …