Mapping the molecular and cellular complexity of cortical malformations

E Klingler, F Francis, D Jabaudon, S Cappello - Science, 2021 - science.org
INTRODUCTION The cerebral cortex, or neocortex, is critical to key mammalian skills such
as language, sociability, and sensorimotor control. This structure consists of dozens of …

Length of the neurogenic period—a key determinant for the generation of upper-layer neurons during neocortex development and evolution

BK Stepien, S Vaid, WB Huttner - Frontiers in cell and developmental …, 2021 - frontiersin.org
The neocortex, a six-layer neuronal brain structure that arose during the evolution of, and is
unique to, mammals, is the seat of higher order brain functions responsible for human …

Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex

L Telley, G Agirman, J Prados, N Amberg, S Fièvre… - Science, 2019 - science.org
INTRODUCTION The cerebral cortex is a cellularly heterogeneous structure whose
neuronal circuits underlie high-order cognitive and sensorimotor information processing …

Temporal controls over inter-areal cortical projection neuron fate diversity

E Klingler, U Tomasello, J Prados, JM Kebschull… - Nature, 2021 - nature.com
Interconnectivity between neocortical areas is critical for sensory integration and
sensorimotor transformations,,,,–. These functions are mediated by heterogeneous inter …

Dense functional and molecular readout of a circuit hub in sensory cortex

C Condylis, A Ghanbari, N Manjrekar, K Bistrong… - Science, 2022 - science.org
INTRODUCTION The diversity of cell types is a defining feature of the neuronal circuitry that
makes up the areas and layers of the mammalian cortex. At a molecular level, the extent of …

[HTML][HTML] Gabrb3 is required for the functional integration of pyramidal neuron subtypes in the somatosensory cortex

R Babij, C Ferrer, A Donatelle, S Wacks, AM Buch… - Neuron, 2023 - cell.com
Dysfunction of gamma-aminobutyric acid (GABA) ergic circuits is strongly associated with
neurodevelopmental disorders. However, it is unclear how genetic predispositions impact …

Making Ramón y Cajal proud: Development of cell identity and diversity in the cerebral cortex

DJ Di Bella, N Domínguez-Iturza, JR Brown, P Arlotta - Neuron, 2024 - cell.com
Since the beautiful images of Santiago Ramón y Cajal provided a first glimpse into the
immense diversity and complexity of cell types found in the cerebral cortex, neuroscience …

From cell types to an integrated understanding of brain evolution: the case of the cerebral cortex

MA Tosches - Annual Review of Cell and Developmental …, 2021 - annualreviews.org
With the discovery of the incredible diversity of neurons, Cajal and coworkers laid the
foundation of modern neuroscience. Neuron types are not only structural units of nervous …

Single-cell multiomics atlas of organoid development uncovers longitudinal molecular programs of cellular diversification of the human cerebral cortex

A Uzquiano, AJ Kedaigle, M Pigoni, B Paulsen… - BioRxiv, 2022 - biorxiv.org
Realizing the full utility of brain organoids as experimental systems to study human cortical
development requires understanding whether organoids replicate the cellular and molecular …

Transcription factor expression defines subclasses of developing projection neurons highly similar to single-cell RNA-seq subtypes

WE Heavner, S Ji, JH Notwell… - Proceedings of the …, 2020 - National Acad Sciences
We are only just beginning to catalog the vast diversity of cell types in the cerebral cortex.
Such categorization is a first step toward understanding how diversification relates to …