Brain‐derived neurotrophic factor, depression, and physical activity: making the neuroplastic connection

C Phillips - Neural plasticity, 2017 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) is a neurotrophin that is vital to the survival,
growth, and maintenance of neurons in key brain circuits involved in emotional and …

BDNF and hippocampal synaptic plasticity

G Leal, CR Bramham, CB Duarte - Vitamins and hormones, 2017 - Elsevier
Brain-derived neurotrophic factor (BDNF) belongs to a family of small secreted proteins that
also include nerve growth factor, neurotrophin 3, and neurotrophin 4. BDNF stands out …

The role of BDNF on neural plasticity in depression

T Yang, Z Nie, H Shu, Y Kuang, X Chen… - Frontiers in cellular …, 2020 - frontiersin.org
Using behavioral, pharmacological, and molecular methods, lots of studies reveal that
depression is closely related to the abnormal neural plasticity processes occurring in the …

The physiology of regulated BDNF release

T Brigadski, V Leßmann - Cell and Tissue Research, 2020 - Springer
The neurotrophic factor BDNF is an important regulator for the development of brain circuits,
for synaptic and neuronal network plasticity, as well as for neuroregeneration and …

Targeting neurotrophins to specific populations of neurons: NGF, BDNF, and NT-3 and their relevance for treatment of spinal cord injury

KM Keefe, IS Sheikh, GM Smith - International journal of molecular …, 2017 - mdpi.com
Neurotrophins are a family of proteins that regulate neuronal survival, synaptic function, and
neurotransmitter release, and elicit the plasticity and growth of axons within the adult central …

Brain-derived neurotrophic factor in mood disorders and antidepressant treatments

E Castrén, M Kojima - Neurobiology of disease, 2017 - Elsevier
Levels of brain-derived neurotrophic factor (BDNF) are reduced in the brain and serum of
depressed patients and at least the reduction in serum levels is reversible upon successful …

[HTML][HTML] The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function

MF Egan, M Kojima, JH Callicott, TE Goldberg… - Cell, 2003 - cell.com
Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity and
hippocampal-dependent memory in cell models and in animals. We examined the effects of …

A simple role for BDNF in learning and memory?

C Cunha, R Brambilla, KL Thomas - Frontiers in molecular …, 2010 - frontiersin.org
Since its discovery almost three decades ago, the secreted neurotrophin brain-derived
neurotrophic factor (BDNF) has been firmly implicated in the differentiation and survival of …

The yin and yang of neurotrophin action

B Lu, PT Pang, NH Woo - Nature Reviews Neuroscience, 2005 - nature.com
Neurotrophins have diverse functions in the CNS. Initially synthesized as precursors
(proneurotrophins), they are cleaved to produce mature proteins, which promote neuronal …

Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease

MG Murer, Q Yan, R Raisman-Vozari - Progress in neurobiology, 2001 - Elsevier
Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to
nerve growth factor, which is abundantly and widely expressed in the adult mammalian …