[HTML][HTML] RAS proteins and their regulators in human disease
DK Simanshu, DV Nissley, F McCormick - Cell, 2017 - cell.com
RAS proteins are binary switches, cycling between ON and OFF states during signal
transduction. These switches are normally tightly controlled, but in RAS-related diseases …
transduction. These switches are normally tightly controlled, but in RAS-related diseases …
[HTML][HTML] Deregulation of HLA-I in cancer and its central importance for immunotherapy
It is now well accepted that many tumors undergo a process of clonal selection which means
that tumor antigens arising at various stages of tumor progression are likely to be …
that tumor antigens arising at various stages of tumor progression are likely to be …
[HTML][HTML] Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting
Activating RAS missense mutations are among the most prevalent genomic alterations
observed in human cancers and drive oncogenesis in the three most lethal tumor types …
observed in human cancers and drive oncogenesis in the three most lethal tumor types …
High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D
Complete cancer regression occurs in a subset of patients following adoptive T cell therapy
(ACT) of ex vivo expanded tumor-infiltrating lymphocytes (TILs). However, the low success …
(ACT) of ex vivo expanded tumor-infiltrating lymphocytes (TILs). However, the low success …
Unveiling the peptide motifs of HLA-C and HLA-G from naturally presented peptides and generation of binding prediction matrices
M Di Marco, H Schuster, L Backert… - The Journal of …, 2017 - journals.aai.org
The classical HLA-C and the nonclassical HLA-E and HLA-G molecules play important roles
both in the innate and adaptive immune system. Starting already during embryogenesis and …
both in the innate and adaptive immune system. Starting already during embryogenesis and …
Tumor immunity and survival as a function of alternative neopeptides in human cancer
The immune system exerts antitumor activity via T cell–dependent recognition of tumor-
specific antigens. Although the number of tumor neopeptides—peptides derived from …
specific antigens. Although the number of tumor neopeptides—peptides derived from …
Genome-editing technologies in adoptive T cell immunotherapy for cancer
Abstract Purpose of Review In this review, we discuss the most recent developments in gene-
editing technology and discuss their application to adoptive T cell immunotherapy. Recent …
editing technology and discuss their application to adoptive T cell immunotherapy. Recent …
Cancer vaccines: Targeting KRAS-driven cancers
Y Zhang, JA Ma, HX Zhang, YN Jiang… - Expert Review of …, 2020 - Taylor & Francis
Introduction: Mutant KRAS is a genetic driver of multiple cancers that has challenged clinical
anti-cancer therapeutics in the last 3 decades. Neo-antigens encoded by KRAS mutations …
anti-cancer therapeutics in the last 3 decades. Neo-antigens encoded by KRAS mutations …
Kras and tumor immunity: friend or foe?
J Cullis, S Das, D Bar-Sagi - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
With the recent breakthroughs in immunotherapy as curative treatments in certain tumor
types, there has been renewed interest in the relationship between immunity and tumor …
types, there has been renewed interest in the relationship between immunity and tumor …
[HTML][HTML] Adoptive cell transfer: is it a promising immunotherapy for colorectal cancer?
J Fan, D Shang, B Han, J Song, H Chen, JM Yang - Theranostics, 2018 - ncbi.nlm.nih.gov
The last decade has witnessed significant advances in the adoptive cell transfer (ACT)
technique, which has been appreciated as one of the most promising treatments for patients …
technique, which has been appreciated as one of the most promising treatments for patients …