To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …

Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

The development of chemotherapy resistance is the most vital obstacle to clinical efficacy in
gastric cancer (GC). The dysregulation of the Wnt/beta-catenin signaling pathway is critically …

Wnt signaling is one of the key cascades regulating development and stemness, and has
also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has …

Abstract Background Circular RNA (circRNA), a subclass of non-coding RNA, plays a critical
role in cancer tumorigenesis and metastasis. It has been suggested that circRNA acts as a …

Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key
cellular functions including proliferation, differentiation, migration, genetic stability …

Gastric cancers, with gastric adenocarcinoma (GAC) as the most common histological type,
impose a considerable global health burden. Although the screening strategies for early …

Background Gastric cancer (GC) is a common malignancy and frequent cause of cancer-
related death. Long non-coding RNAs (lncRNAs) have emerged as important regulators and …

Background & Aims We previously established long-term, 3-dimensional culture of
organoids from mouse tissues (intestine, stomach, pancreas, and liver) and human intestine …

Abstract N6‐methyladenosine (m6A) modulators decide the fate of m6A‐modified transcripts
and drive cancer development. RNA interference targeting m6A modulators promise to be …