Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis

FD Ni, SL Hao, WX Yang - Cell death & disease, 2019 - nature.com
The functions of Sertoli cells in spermatogenesis have attracted much more attention
recently. Normal spermatogenesis depends on Sertoli cells, mainly due to their influence on …

The blood-testis barrier and its implications for male contraception

CY Cheng, DD Mruk, DR Sibley - Pharmacological reviews, 2012 - Elsevier
The blood-testis barrier (BTB) is one of the tightest blood-tissue barriers in the mammalian
body. It divides the seminiferous epithelium into the basal and the apical (adluminal) …

A local autocrine axis in the testes that regulates spermatogenesis

CY Cheng, DD Mruk - Nature Reviews Endocrinology, 2010 - nature.com
Spermiation—the release of mature spermatozoa from Sertoli cells into the seminiferous
tubule lumen—occurs by the disruption of an anchoring device known as the apical …

Cross-talk between nuclear receptors and nuclear factor κB

K De Bosscher, W Vanden Berghe, G Haegeman - Oncogene, 2006 - nature.com
A variety of studies have shown that some activated nuclear receptors (NRs), especially the
glucorticoid receptor, the estrogen receptor and peroxisome proliferator-activated receptor …

Nanoparticles and spermatogenesis: how do nanoparticles affect spermatogenesis and penetrate the blood–testis barrier

Z Lan, WX Yang - Nanomedicine, 2012 - Taylor & Francis
Due to the widespread use of nanomaterials in medical, industrial and military applications,
the question as to whether nanoparticles (NPs) cause harmful disturbances in human …

Regulation of spermatogenesis in the microenvironment of the seminiferous epithelium: new insights and advances

CY Cheng, EWP Wong, HHN Yan, DD Mruk - Molecular and cellular …, 2010 - Elsevier
Spermatogenesis is a complex biochemical event, involving the participation of the
hypothalamus and the pituitary gland via secretion of the hypothalamus hormone GnRH …

Endocrine regulation of spermatogenesis

L O'Donnell, SJ Meachem, PG Stanton… - Knobil and Neill's …, 2006 - research.monash.edu
Spermatogenesis occurs within the seminiferous tubules of the testis, in close association
with the somatic cells of the seminiferous epithelium, the Sertoli cells. At the completion of …

The role of tumor necrosis factor-alpha and interleukin-1 in the mammalian testis and their involvement in testicular torsion and autoimmune orchitis

JJ Lysiak - Reproductive Biology and Endocrinology, 2004 - Springer
This review will focus the roles of TNF-alpha, IL-1 alpha, and IL-1 beta in the mammalian
testis and in two testicular pathologies, testicular torsion and orchitis. TNF alpha in the testis …

Cross-talk between the androgen receptor and the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer

Y Wang, JI Kreisberg, PM Ghosh - Current cancer drug targets, 2007 - ingentaconnect.com
Prostate cancer is initially dependent on androgens for growth; hence, recurrent prostate is
treated with androgen ablation which may result in progression to androgen independence …

[HTML][HTML] Testosterone supplementation in aging men and women: possible impact on cardiovascular-renal disease

JF Reckelhoff, LL Yanes, R Iliescu… - American Journal …, 2005 - journals.physiology.org
Abstract Treatment of aging men and women with testosterone supplements is increasing.
The supplements are given to postmenopausal women mainly to improve their libido and to …