DNA damage created by endogenous or exogenous genotoxic agents can exist in multiple
forms, and if allowed to persist, can promote genome instability and directly lead to various …

This perspective reviews the many dimensions of base excision repair from a 10,000 foot
vantage point and provides one person's view on where the field is headed. Enzyme …

Deficiency in repair of nuclear and mitochondrial DNA damage has been linked to several
neurodegenerative disorders. Many recent experimental results indicate that the post-mitotic …

Oxidatively induced DNA damage is caused in living organisms by endogenous and
exogenous reactive species. DNA lesions resulting from this type of damage are mutagenic …

Endogenous and exogenous sources cause oxidatively induced DNA damage in living
organisms by a variety of mechanisms. The resulting DNA lesions are mutagenic and …

DNA damage is a natural hazard of life. The most common DNA lesions are base, sugar,
and single-strand break damage resulting from oxidation, alkylation, deamination, and …

The expansion of repeated sequences is the cause of over 30 inherited genetic diseases,
including Huntington disease, myotonic dystrophy (types 1 and 2), fragile X syndrome, many …

Hydroxyl radical (HO•) is the most reactive toward DNA among the reactive oxygen species
(ROS) generated in aerobic organisms by cellular metabolisms. HO• is generated also by …

Cockayne syndrome (CS) is a devastating autosomal recessive disease characterized by
neurodegeneration, cachexia, and accelerated aging. 80% of the cases are caused by …

Both endogenous processes and exogenous physical and chemical sources generate
deoxyribonucleic acid (DNA) damage in the nucleus and organelles of living cells. To …