Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and
associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in
lipid metabolism and a revolutionary therapeutic target for hypercholesterolemia and its …

The use of preclinical animal models of psoriasis has significantly increased over the last
three decades, with each model having unique strengths and limitations. Some models …

Psoriasis is a chronic autoinflammatory skin disease associated with multiple comorbidities,
with a prevalence ranging from 2 to 3% in the general population. Decades of preclinical …

Importance Lipid pathways have been implicated in the pathogenesis of psoriasis, and
some lipid-lowering drugs, such as statins, are hypothesized to have disease-modifying …

The increasing prevalence of Metabolic syndrome (MetS) is a worldwide health problem,
and the association between MetS and skin diseases has recently attracted growing …

Cardiovascular diseases (CVD) are the leading cause of death worldwide. Since the
establishment of the “lipid hypothesis”, according to which, cholesterol level is directly …

Proprotein convertase subtilisin/kexin type-9 (PCSK9) is a posttranslational regulator of the
LDL receptor (LDLR). Recent studies have proposed a role for PCSK9 in regulating immune …

There is increasing interest in the association between psoriasis and non-alcoholic fatty liver
disease (NAFLD), which is a prevalent liver disease characterized by excessive fat storage …

Psoriasis is an incurable skin disease that develops in about two-thirds of patients before the
age of 40 and requires lifelong treatment; its pathological mechanisms have not been fully …