There is accumulating evidence that platelets play roles beyond their traditional functions in
thrombosis and hemostasis, eg, in inflammatory processes, infection and cancer, and that …

Abstract The glycoprotein (GP) Ib-IX complex is a platelet receptor that mediates the initial
interaction with subendothelial von Willebrand factor (VWF) causing platelet arrest at sites of …

Abstract The glycoprotein Ib–IX (GPIb-IX) complex mediates initial platelet adhesion to von
Willebrand factor (VWF) immobilized on subendothelial matrix and endothelial surfaces, and …

Bionanocomposites (BNCs) have gained significant attention in the field of biomaterials,
particularly for their potential applications in skin tissue repair and regeneration. Advantages …

Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder with an incompletely
understood pathophysiology but includes platelet-clearance in the spleen and liver via T …

Abstract Glycoprotein (GP) Ib-IX-V is the second most abundant platelet receptor for
thrombin and other ligands crucial for hemostasis and thrombosis. Its activity is involved in …

Hydrogen sulfide (H 2 S) shows promise in treating myocardial ischemia-reperfusion injury
(MIRI), but the challenge of controlled and sustained release hinders its clinical utility. In this …

Abstract Background Glycoprotein (GP) Ibα plays a critical role in regulating platelet
clearance. Recently, we identified the mechanosensory domain (MSD) in GPIbα and …

Cardiovascular disease (CVD) is a major cause of death worldwide. Although there are
many variables that contribute to the development of this disease, it is predominantly the …

Platelets lacking O-glycans exhibit a reduced lifespan and increased clearance in the liver
due to defective sialylation. 1, 2 Variations in O-glycosylation affect platelet functions and …