The flavonoid silymarin extracted from the seeds of Sylibum marianum is a mixture of 6
flavolignan isomers. The 3 more important isomers are silybin (or silibinin), silydianin, and …

Neuroblastoma is an embryonal malignancy that commonly affects young children and is
remarkably heterogenous in its malignant potential. Recently, the genetic basis of …

Colorectal cancer (CRC) is the most common malignant tumor of digestive system. The aim
of this study was to identify gene signatures during CRC and uncover their potential …

G protein-coupled receptors (GPCRs) regulate an array of fundamental biological
processes, such as growth, metabolism and homeostasis. Specifically, GPCRs are involved …

Purpose: We undertook a multidimensional clinical genomics study of children and
adolescent young adults with relapsed and refractory cancers to determine the feasibility of …

Cell motility is a crucial biological process that plays a critical role in the development of
multicellular organisms and is essential for tissue formation and regeneration. However …

The molecular mechanisms underlying the aggressive behavior of MYCN driven
neuroblastoma (NBL) is under intense investigation; however, little is known about the …

Neuroblastoma is the most common extracranial solid tumor in children. The chromatin
remodeler ATRX is frequently mutated in high‐risk patients with a poor prognosis. Although …

Protein homeostasis is well accepted as the prerequisite for proper operation of various life
activities. As the main apparatus of protein translation, ribosomes play an indispensable role …

Background It has been demonstrated by studies globally that RNA binding proteins (RBPs)
took part in the development of cervical cancer (CC). Few studies concentrated on the …