Epigenetic alterations in glioblastomas: Diagnostic, prognostic and therapeutic relevance

L Montella, M Cuomo, N Del Gaudio… - … Journal of Cancer, 2023 - Wiley Online Library
Glioblastoma, the most common and heterogeneous tumor affecting brain parenchyma, is
dismally characterized by a very poor prognosis. Thus, the search of new, more effective …

Glioma lateralization: Focus on the anatomical localization and the distribution of molecular alterations

NT Cini, M Pennisi, S Genc… - Oncology …, 2024 - spandidos-publications.com
It is well known how the precise localization of glioblastoma multiforme (GBM) predicts the
direction of tumor spread in the surrounding neuronal structures. The aim of the present …

[HTML][HTML] Photodynamic therapy for glioblastoma: a light at the end of the tunnel

M Miretti, MAG Graglia, AI Suárez, CG Prucca - Journal of Photochemistry …, 2023 - Elsevier
Glioblastomas (GBM) are considered one of the most aggressive tumors of the central
nervous system. The standard treatment for GBM-diagnosed patients implies surgery …

[HTML][HTML] Downregulation of MGMT expression by targeted editing of DNA methylation enhances temozolomide sensitivity in glioblastoma

X Han, MOE Abdallah, P Breuer, F Stahl, Y Bakhit… - Neoplasia, 2023 - Elsevier
Glioblastoma is the most common and aggressive primary tumor of the central nervous
system with poor outcome. Current gold standard treatment is surgical resection followed by …

Prenatal BRCA1 epimutations contribute significantly to triple-negative breast cancer development

O Nikolaienko, HP Eikesdal, E Ognedal, B Gilje… - Genome Medicine, 2023 - Springer
Background Normal cell BRCA1 epimutations have been associated with increased risk of
triple-negative breast cancer (TNBC). However, the fraction of TNBCs that may have BRCA1 …

Progress in glioma stem cell research

V Ramar, S Guo, BA Hudson, M Liu - Cancers, 2023 - mdpi.com
Simple Summary Glioblastoma stands as the most aggressive form of adult brain cancer,
often resulting in a median survival of 14.6 months even following surgical intervention …

[HTML][HTML] Bioactive compounds from Actinidia arguta fruit as a new strategy to fight glioblastoma

C Macedo, PC Costa, F Rodrigues - Food Research International, 2024 - Elsevier
In recent years, there has been a significant demand for natural products as a mean of
disease prevention or as an alternative to conventional medications. The driving force for …

Integrated Gene Expression Data‐Driven Identification of Molecular Signatures, Prognostic Biomarkers, and Drug Targets for Glioblastoma

MW Alom, MDK Jibon, MO Faruqe… - BioMed Research …, 2024 - Wiley Online Library
Glioblastoma (GBM) is a highly prevalent and deadly brain tumor with high mortality rates,
especially among adults. Despite extensive research, the underlying mechanisms driving its …

Comprehensive pan-cancer analysis reveals ENC1 as a promising prognostic biomarker for tumor microenvironment and therapeutic responses

Z Cao, J Zhu, Z Wang, Y Peng, L Zeng - Scientific Reports, 2024 - nature.com
Accumulating research showed that ENC1 plays a critical role in maintaining the
physiological functions. However, little is known about its role in predicting prognosis and …

Pyrosequencing Analysis of O-6-Methylguanine-DNA Methyltransferase Methylation at Different Cut-Offs of Positivity Associated with Treatment Response and …

FFV Silva, M Di Domenico, VCA Caponio… - International Journal of …, 2024 - mdpi.com
The O-6-methylguanine-DNA methyltransferase (MGMT) gene is a critical guardian of
genomic integrity. MGMT methylation in diffuse gliomas serves as an important determinant …