Small-ring heterocycles have found many applications both as useful starting materials in
the synthesis of more elaborate structures and as valuable targets of synthesis. Our review …

Protein phosphatase 2A (PP 2A) is a serine/threonine phosphatase involved in the
regulation of many cellular processes. A confirmed tumor suppressor protein, PP 2A is …

Screening of small-molecule libraries is a productive method for identifying both chemical
probes of disease-related targets and potential starting points for drug discovery. In this …

Kinases are principal components of signal transduction pathways and the focus of intense
basic and drug discovery research. Irreversible inhibitors that covalently modify non-catalytic …

Eukaryotic and prokaryotic organisms possess huge numbers of uncharacterized enzymes.
Selective inhibitors offer powerful probes for assigning functions to enzymes in native …

The sensitivity of fluorescence polarization (FP) and fluorescence anisotropy (FA) to
molecular weight changes has enabled the interrogation of diverse biological mechanisms …

Serine hydrolases (SHs) consist of> 200 enzymes in humans characterized by the presence
of an active site serine that is used for the hydrolysis of substrates. The membership of this …

Abstract Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase that
regulates many cellular processes. Given the central role of PP2A in regulating diverse …

Cells produce electrophilic products with the potential to modify and affect the function of
proteins. Chemoproteomic methods have provided a means to qualitatively inventory …

Serine hydrolases perform crucial roles in many biological processes, and several of these
enzymes are targets of approved drugs for indications such as type 2 diabetes, Alzheimer's …