Personalized management of pheochromocytoma and paraganglioma

S Nölting, N Bechmann, D Taieb… - Endocrine …, 2022 - academic.oup.com
Pheochromocytomas/paragangliomas are characterized by a unique molecular landscape
that allows their assignment to clusters based on underlying genetic alterations. With around …

Biochemical assessment of pheochromocytoma and paraganglioma

G Eisenhofer, C Pamporaki, JWM Lenders - Endocrine reviews, 2023 - academic.oup.com
Pheochromocytoma and paraganglioma (PPGL) require prompt consideration and efficient
diagnosis and treatment to minimize associated morbidity and mortality. Once considered …

Targeted therapies in pheochromocytoma and paraganglioma

K Wang, J Crona, F Beuschlein… - The Journal of …, 2022 - academic.oup.com
Molecular targeted therapy plays an increasingly important role in the treatment of metastatic
pheochromocytomas and paragangliomas (PPGLs), which are rare tumors but remain …

Pheochromocytoma: a changing perspective and current concepts

A Kiriakopoulos, P Giannakis… - … in endocrinology and …, 2023 - journals.sagepub.com
This article aims to review current concepts in diagnosing and managing
pheochromocytoma and paraganglioma (PPGL). Personalized genetic testing is vital, as 40 …

Metastatic pheochromocytoma and paraganglioma: somatostatin receptor 2 expression, genetics, and therapeutic responses

A Fischer, S Kloos, U Maccio, J Friemel… - The Journal of …, 2023 - academic.oup.com
Abstract Context Pheochromocytomas and paragangliomas (PPGLs) with pathogenic
mutations in the succinate dehydrogenase subunit B (SDHB) are associated with a high …

The pheochromocytoma/paraganglioma syndrome: an overview on mechanisms, diagnosis and management

JV Lima, CE Kater - International braz j urol, 2023 - SciELO Brasil
Pheochromocytomas/paragangliomas (PPGL) are rare, metastatic, and potentially fatal
neuroendocrine tumors, often neglected because they present symptoms similar to other …

[HTML][HTML] Pre-clinical phaeochromocytoma and paraganglioma models: cell lines, animal models, and a human primary culture model

K Wang, A Fischer, U Maccio, C Hantel… - Best Practice & …, 2024 - Elsevier
While the establishment of human phaeochromocytoma and paraganglioma (PPGL) cell
lines has proven to be particularly difficult over several decades of research, there are other …

Personalized drug testing in human pheochromocytoma/paraganglioma primary cultures

K Wang, I Schütze, S Gulde… - Endocrine-Related …, 2022 - erc.bioscientifica.com
Aggressive pheochromocytomas and paragangliomas (PPGLs) are difficult to treat, and
molecular targeting is being increasingly considered, but with variable results. This study …

Adrenal medulla development and medullary-cortical interactions

N Bechmann, I Berger, SR Bornstein… - Molecular and Cellular …, 2021 - Elsevier
The mammalian adrenal gland is composed of two distinct tissue types in a bidirectional
connection, the catecholamine-producing medulla derived from the neural crest and the …

Impact of sex hormones on pheochromocytomas, paragangliomas, and gastroenteropancreatic neuroendocrine tumors

K Wang, A Fischer, U Maccio, K Zitzmann… - European Journal of …, 2025 - academic.oup.com
Objective The effects of sex hormones remain largely unexplored in pheochromocytomas
and paragangliomas (PPGLs) and gastroenteropancreatic neuroendocrine tumors (GEP …