The transient receptor potential (TRP) channel superfamily consists of 28 mammalian cation
channels and is expressed in almost every tissue, including the heart and vasculature; most …

Although asymptomatic in most patients, extrarenal manifestations of ADPKD may become
more clinically relevant with the increasing life expectancy of affected patients. They mainly …

Our current knowledge of human biology is often based on studying a wide range of animal
species. In particular, for understanding human diseases, the development of adequate …

Mechano-gated ion channels play a key physiological role in cardiac, arterial, and skeletal
myocytes. For instance, opening of the non-selective stretch-activated cation channels in …

There are many genetic syndromes associated with the aortic aneurysmal disease which
include Marfan syndrome (MFS), Ehlers‐Danlos syndrome (EDS), Loeys‐Dietz syndrome …

Background Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder
associated with high incidences of intracranial aneurysms. We performed a systematic …

Mutations in the polycystins PC1 or PC2 cause autosomal dominant polycystic kidney
disease (ADPKD), which is characterized by the formation of fluid-filled renal cysts that …

Key points• Intravascular pressure is reported to activate several mechanosensitive ion
channels, leading to smooth muscle cell (SMC) depolarization, voltage‐dependent Ca2+ …

Autosomal dominant polycystic kidney disease is a common disorder, affecting
approximately one in 1,000 individuals. This disease is characterized by the presence of …

Mutations of the two polycystins, PC1 and PC2, lead to polycystic kidney disease.
Polycystins are able to form complexes with numerous families of proteins that have been …