The endocytosis mechanism is a complicated system that is essential for cell signaling and
survival. Megalin, a membrane-associated endocytic receptor, and its related proteins such …

Proximal tubule protein uptake is mediated by 2 receptors, megalin and cubilin. These
receptors rescue a variety of filtered ligands, including biomarkers, essential vitamins, and …

The ability to take up substances from the surrounding environment not only provides cells
with vital nutrients, but also enables the selective transport of substances from one …

The multiligand, endocytic receptors megalin and cubilin are colocalized in the renal
proximal tubule. They are heavily expressed in the apical endocytic apparatus. Megalin is a …

Steroid hormones are central regulators of a variety of biological processes. According to the
free hormone hypothesis, steroids enter target cells by passive diffusion. However, recently …

Using affinity chromatography and surface plasmon resonance analysis, we have identified
cubilin, a 460-kDa receptor heavily expressed in kidney proximal tubule epithelial cells, as …

Proteins filtered in renal glomeruli are removed from the tubular fluid by endocytosis in the
proximal tubule mediated by the two receptors megalin and cubilin. After endocytic uptake …

Breed Predispositions to Disease in Dogs and Cats, Third Edition provides a comprehensive
exploration of current knowledge of breed predispositions based on rigorous examination of …

Disorders of cobalamin (vitamin B12) metabolism are increasingly recognized in small
animal medicine and have a variety of causes ranging from chronic gastrointestinal disease …

The present study sought to determine the spectrum of diseases associated with subnormal
concentrations of serum cobalamin in cats undergoing investigation of suspected …