N TRK gene fusions involving either NTRK1, NTRK2 or NTRK3 (encoding the neurotrophin
receptors TRKA, TRKB and TRKC, respectively) are oncogenic drivers of various adult and …

▪ Abstract Despite considerable evidence that neuronal activity influences the organization
and function of circuits in the developing and adult brain, the molecular signals that translate …

In contrast with the prevailing view that most tumors and metastases begin as avascular
masses, evidence is presented here that a subset of tumors instead initially grows by …

This 1999 edition of The Neural Crest contains comprehensive information about the neural
crest, a structure unique to the vertebrate embryo, which has only a transient existence in …

TIE2 is a receptor-like tyrosine kinase expressed almost exclusively in endothelial cells and
early hemopoietic cells and required for the normal development of vascular structures …

Brain-derived neurotrophic factor (BDNF) is expressed at high levels in hippocampal
neurons, and its expression is modulated by neural activity. Knockout mice can be used to …

Accumulating evidence indicates that the Trk family of tyrosine protein kinase receptors, Trk
(also known as TrkA), TrkB, and TrkC, are responsible for mediating the trophic effects of the …

The neurotrophins are growth factors that play critical roles in the development,
maintenance, survival, and death of the nervous system. The signal transducing systems …

Nerve growth factor (NGF) has long occupied a central position in developmental
neurobiology because of the many important neuronal functions it has been shown to …

The signaling molecules that elicit embryonic induction of the liver from the mammalian gut
endoderm or induction of other gut-derived organs are unknown. Close proximity of cardiac …