[HTML][HTML] Mitochondrial dysfunction at the crossroad of cardiovascular diseases and cancer
A large body of evidence indicates the existence of a complex pathophysiological
relationship between cardiovascular diseases and cancer. Mitochondria are crucial …
relationship between cardiovascular diseases and cancer. Mitochondria are crucial …
[HTML][HTML] Engineered biomaterial delivery strategies are used to reduce cardiotoxicity in osteosarcoma
Y Hou, J Wang, J Wang - Frontiers in Pharmacology, 2023 - frontiersin.org
Osteosarcoma (OS) is the most common malignant bone tumor in children and adolescents.
Chemotherapy drugs play an integral role in OS treatment. Preoperative neoadjuvant …
Chemotherapy drugs play an integral role in OS treatment. Preoperative neoadjuvant …
Schisandrin C enhances type I IFN response activation to reduce tumor growth and sensitize chemotherapy through antitumor immunity
H Yang, X Zhan, J Zhao, W Shi, T Liu, Z Wei… - Frontiers in …, 2024 - frontiersin.org
With the advancing comprehension of immunology, an increasing number of
immunotherapies are being explored and implemented in the field of cancer treatment. The …
immunotherapies are being explored and implemented in the field of cancer treatment. The …
[HTML][HTML] Reducing the effective dose of cisplatin using cobalt modified silver nano-hybrid as a carriers on MCF7 and HCT cell models
AH Faid, MA Ramadan - BMC chemistry, 2024 - Springer
Cancer is a deadly illness with a convoluted pathogenesis. The most prevalent restrictions
that frequently result in treatment failure for cancer chemotherapy include lack of selectivity …
that frequently result in treatment failure for cancer chemotherapy include lack of selectivity …
Small Molecule Targeting PPM1A Activates Autophagy for Mycobacterium tuberculosis Host-Directed Therapy
Z Yu, YC Liang, S Berton, L Liu, J Zou… - Journal of Medicinal …, 2024 - ACS Publications
Mycobacterium tuberculosis (Mtb), the infectious agent of tuberculosis (TB), causes over 1.5
million deaths globally every year. Host-directed therapies (HDT) for TB are desirable for …
million deaths globally every year. Host-directed therapies (HDT) for TB are desirable for …
Malate, a natural inhibitor of 6PGD, improves the efficacy of chemotherapy in lung cancer
M Sun, Q Feng, Q Yan, H Zhao, H Wang, S Zhang… - Lung Cancer, 2024 - Elsevier
Objective Metabolic reprogramming is an important coordinator of tumor development and
resistance to therapy, such as the tendency of tumor cells to utilize glycolytic energy rather …
resistance to therapy, such as the tendency of tumor cells to utilize glycolytic energy rather …
A mechanism–based perspective on the interplay of new drug candidate with biomolecules
R Behroozi, E Dehghanian… - Journal of Molecular …, 2025 - Elsevier
This research deals with the synthesis and analysis of a novel Pd (II) compound,[Pd
(dach)(SA)], featuring 1, 2-diaminocyclohexane (dach) and salicylic acid (SA). The …
(dach)(SA)], featuring 1, 2-diaminocyclohexane (dach) and salicylic acid (SA). The …
[HTML][HTML] Modulating the Activity of the Human Organic Cation Transporter 2 Emerges as a Potential Strategy to Mitigate Unwanted Toxicities Associated with Cisplatin …
A Hucke, M Kantauskaite, TN Köpp, CA Wehe… - International Journal of …, 2024 - mdpi.com
Cisplatin (CDDP) stands out as an effective chemotherapeutic agent; however, its
application is linked to the development of significant adverse effects, notably nephro-and …
application is linked to the development of significant adverse effects, notably nephro-and …
[HTML][HTML] Proto-oncogene c-Myb potentiates cisplatin resistance of ovarian cancer cells by downregulating lncRNA NKILA and modulating cancer stemness and …
XY Zhang, BC Zhu, M He, SS Dong - Journal of Ovarian Research, 2024 - Springer
Ovarian cancer is a major gynecological cancer that has poor prognosis associated mainly
to its late diagnosis. Cisplatin is an FDA approved ovarian cancer therapy and even though …
to its late diagnosis. Cisplatin is an FDA approved ovarian cancer therapy and even though …
[HTML][HTML] AM1172 (a hydrolysis-resistant endocannabinoid analog that inhibits anandamide cellular uptake) reduces the viability of the various melanoma cells, but it …
P Marzęda, P Wróblewska-Łuczka… - Pharmacological …, 2024 - Springer
Background Despite great advances in our understanding of the impact of cannabinoids on
human organism, many of their properties still remain undetermined, including their potential …
human organism, many of their properties still remain undetermined, including their potential …