This position paper, led by the NRG Oncology Particle Therapy Work Group, focuses on the
concept of relative biologic effect (RBE) in clinical proton therapy, with the goal of providing …

Abstract Background and Purpose Radiation-induced brainstem necrosis after proton
therapy is a severe toxicity with potential association to uncertainties in the proton relative …

Objective. This study aims to address the limitations of traditional methods for calculating
linear energy transfer (LET), a critical component in assessing relative biological …

Radiation-induced brainstem necrosis is a severe toxicity that can occur following
radiotherapy of tumours in the vicinity of the brainstem [1, 2]. Paediatric patients may be …

Objective. While a constant relative biological effectiveness (RBE) of 1.1 forms the basis for
clinical proton therapy, variable RBE models are increasingly being used in plan evaluation …

Purpose Proton therapy is the preferred treatment modality for most pediatric central nervous
system tumors. The risk of radiation necrosis may be increased at the distal end of the beam …

New techniques and technologies are continuously emerging and developing in radiation
oncology. The ongoing aim of much physics-based research is to improve the overall …

Methods: A narrative review was performed through database searching. The search
strategy was conducted in PubMed and Embase. 53 records were included in the final data …

Abstract Background and Purpose Radiotherapy for paediatric posterior fossa tumours may
cause complications in the brainstem and upper spinal cord due to high doses. With proton …