Autophagy is a lysosome-based degradative process used to recycle obsolete cellular
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …

In recent years, rapid discoveries have been made relating to Ca 2+ handling at specific
organelles that have important implications for whole-cell Ca 2+ homeostasis. In particular …

Lysosomes are ubiquitous membrane-bound intracellular organelles with an acidic interior.
They are central for degradation and recycling of macromolecules delivered by endocytosis …

Lysosomal storage diseases (LSDs) are a family of disorders that result from inherited gene
mutations that perturb lysosomal homeostasis. LSDs mainly stem from deficiencies in …

Lysosomal storage disorders (LSDs)—designated as' orphan'diseases—are inborn errors of
metabolism caused by defects in genes that encode proteins involved in various aspects of …

Ca 2+ is a highly versatile intracellular signal that operates over a wide temporal range to
regulate many different cellular processes. An extensive Ca 2+-signalling toolkit is used to …

Abstract Macroautophagy (hereafter called 'autophagy') is a cellular process for degrading
and recycling cellular constituents, and for maintenance of cell function. Autophagy initiates …

Summary Presenilin 1 (PS1) deletion or Alzheimer's disease (AD)-linked mutations disrupt
lysosomal acidification and proteolysis, which inhibits autophagy. Here, we establish that …

Macrophages and their monocyte precursors mediate innate immune responses and can
promote a spectrum of phenotypes from pro-inflammatory to pro-resolving. Currently, there …

The membrane proteins CD38 and CD157 belong to an evolutionarily conserved family of
enzymes that play crucial roles in human physiology. Expressed in distinct patterns in most …