We argue for the critical role of oxidative damage in causing the mitochondrial dysfunction of
aging. Oxidants generated by mitochondria appear to be the major source of the oxidative …

Mitochondrial biogenesis is regulated to adapt mitochondrial population to cell energy
demands. Mitochondrial transcription factor A (TFAM) performs several functions for mtDNA …

Free radical reactions are ubiquitous in living things. Studies on the origin and evolution of
life provide a reasonable explanation for the prominent presence of this unruly class of …

Modulation of endogenous cellular defense mechanisms represents an innovative approach
to therapeutic intervention in diseases causing chronic tissue damage, such as in …

Mitochondria are deeply involved in the production of reactive oxygen species through one-
electron carriers in the respiratory chain; mitochondrial structures are also very susceptible …

Mitochondria do not only produce less ATP, but they also increase the production of reactive
oxygen species (ROS) as byproducts of aerobic metabolism in the aging tissues of the …

▪ Abstract In procaryotes, l-carnitine may be used as both a carbon and nitrogen source for
aerobic growth, or the carbon chain may be used selectively following cleavage of …

Harman first suggested in 1972 that mitochondria might be the biological clock in aging,
noting that the rate of oxygen consumption should determine the rate of accumulation of …

Aging is an inevitable biological process that affects most living organisms. Despite the
enormous consequences associated with the aging process, until recently, relatively little …

Mitochondrial DNA (mtDNA) deletions and mutations have been reported to occur with
aging in various tissues. To determine the functional impact of these changes, we measured …