The Lancet Commission on self-harm

P Moran, A Chandler, P Dudgeon, OJ Kirtley, D Knipe… - The Lancet, 2024 - thelancet.com
Executive summary By delivering transformative shifts in societal attitudes and initiating a
radical redesign of mental health care, we can fundamentally improve the lives of people …

[HTML][HTML] Omics approaches to investigate the pathogenesis of suicide

M Boldrini, Y Xiao, T Singh, C Zhu, M Jabbi… - Biological …, 2024 - Elsevier
Suicide is the second leading cause of death in US adolescents and young adults and is
generally associated with a psychiatric disorder. Suicidal behavior has a complex etiology …

Identifying behaviour-related and physiological risk factors for suicide attempts in the UK Biobank

B Zhang, J You, ET Rolls, X Wang, J Kang, Y Li… - Nature human …, 2024 - nature.com
Suicide is a global public health challenge, yet considerable uncertainty remains regarding
the associations of both behaviour-related and physiological factors with suicide attempts …

Increased somatic mosaicism in autosomal and X chromosomes for suicide death

I Otsuka, S Uchiyama, T Shirai, X Liu… - Molecular …, 2024 - nature.com
Mosaic chromosomal alterations (mCAs) are classified as mosaic deletions (loss), copy-
neutral loss of heterozygosity (CN-LOH), and duplications (gain), attracting special attention …

Next-generation precision medicine for suicidality prevention

R Bhagar, SS Gill, H Le-Niculescu, C Yin… - Translational …, 2024 - nature.com
Suicidality remains a clear and present danger in society in general, and for mental health
patients in particular. Lack of widespread use of objective and/or quantitative information …

Novel insights into the genetic architecture of pregnancy glycemic traits from 14,744 Chinese maternities

H Zhu, H Xiao, L Li, M Yang, Y Lin, J Zhou, X Zhang… - Cell Genomics, 2024 - cell.com
Glycemic traits are critical indicators of maternal and fetal health during pregnancy. We
performed genetic analysis for five glycemic traits in 14,744 Chinese pregnant women. Our …

Stress, heritability, and genetic factors influencing depression, PTSD, and suicidal behavior

NH Kalin - American journal of psychiatry, 2023 - Am Psychiatric Assoc
This issue of the Journal brings together papers that further our understanding of the
influences of stress, heritability, and genetic factors mediating the development of …

Is late-onset suicidal behavior a distinct subtype?

K Szanto, A Szücs, LB Kenneally… - The American Journal of …, 2024 - Elsevier
This clinical viewpoint article aims to draw attention to a yet unexplored factor influencing
suicidal behavior: age of onset of suicidal behavior. To tackle the substantial heterogeneity …

New insights into suicidal behavior from large multi-ancestry genetic meta-analysis

EB Binder - American journal of psychiatry, 2023 - Am Psychiatric Assoc
Suicide is the second leading cause of death among 15-to 29-year-olds (1), and a history of
psychiatric disorders is one of the main risk factors. Hence, understanding the causes of and …

[HTML][HTML] Uncommon protein-coding variants associated with suicide attempt in a diverse sample of US Army soldiers

MD Wilkerson, D Hupalo, JC Gray, X Zhang, J Wang… - Biological …, 2024 - Elsevier
Background Suicide is a societal and public health concern of global scale. Identifying
genetic risk factors for suicide attempt can characterize underlying biology and enable early …