Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …

The inositol 1, 4, 5-trisphosphate (InsP3) receptors (InsP3Rs) are a family of Ca2+ release
channels localized predominately in the endoplasmic reticulum of all cell types. They …

Cardiac glycosides are a diverse family of naturally derived compounds that bind to and
inhibit Na+/K+-ATPase. Members of this family have been in clinical use for many years for …

Na+/K+‐ATPase as an energy transducing ion pump has been studied extensively since its
discovery in 1957. Although early findings suggested a role for Na+/K+‐ATPase in …

The search for endogenous digitalis has led to the isolation of ouabain as well as several
additional cardiotonic steroids of the cardenolide and bufadienolide type from blood …

Abstract The Na+-K+-ATPase, or Na+ pump, is a member of the P-type ATPase superfamily.
In addition to pumping ions, Na+-K+-ATPase is engaged in assembly of multiple protein …

Cardiotonic steroids (CTS), long used to treat heart failure, are endogenously produced in
mammals. Among them are the hydrophilic cardenolide ouabain and the more hydrophobic …

The Na, K-ATPase is the membrane “pump” that generates the Na+ and K+ gradients across
the plasma membrane that drives many physiological processes. This enzyme is highly …

We have shown that ouabain activates Src, resulting in subsequent tyrosine phosphorylation
of multiple effectors. Here, we tested if the Na+/K+-ATPase and Src can form a functional …

The sodium pump, Na+/K+-ATPase, could be an important target for the development of anti-
cancer drugs as it serves as a versatile signal transducer, it is a key player in cell adhesion …