Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

JS Loh, WQ Mak, LKS Tan, CX Ng, HH Chan… - … and Targeted Therapy, 2024 - nature.com
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Emerging therapeutic role of gut microbial extracellular vesicles in neurological disorders

B Sun, H Sawant, A Borthakur, JC Bihl - Frontiers in Neuroscience, 2023 - frontiersin.org
Extracellular vesicles (EVs) serve as cell-to-cell and inter-organ communicators by
conveying proteins and nucleic acids with regulatory functions. Emerging evidence shows …

A neurotherapeutic approach with Lacticaseibacillus rhamnosus E9 on gut microbiota and intestinal barrier in MPTP-induced mouse model of Parkinson's disease

B Aktas, B Aslim, DA Ozdemir - Scientific Reports, 2024 - nature.com
The gut microbiota plays a crucial role in neural development and progression of neural
disorders like Parkinson's disease (PD). Probiotics have been suggested to impact …

The gut microbiota–brain axis in neurological disorders

M You, N Chen, Y Yang, L Cheng, H He, Y Cai… - MedComm, 2024 - Wiley Online Library
Previous studies have shown a bidirectional communication between human gut microbiota
and the brain, known as the microbiota–gut–brain axis (MGBA). The MGBA influences the …

[HTML][HTML] Convergence of Neuroinflammation, Microbiota, and Parkinson's Disease: Therapeutic Insights and Prospects

N Domínguez Rojo, M Blanco Benítez, R Cava… - International Journal of …, 2024 - mdpi.com
Parkinson's disease (PD) is a complex neurodegenerative disorder. Recent evidence
reveals connections between neuroinflammatory processes and intestinal microbiota …

Pesticides in foods: towards bioremediation biocatalysts?

G Perpetuini, PA Nzobouh Fossi, S Kwak, O Namessi… - Catalysts, 2023 - mdpi.com
The presence of hazardous chemical compounds in foods is a growing concern in almost
every country. Although some toxins come from microbial contamination, a major part comes …

Crosstalk between gut–brain axis: unveiling the mysteries of gut ROS in progression of Parkinson's disease

D Soni, S Upadhayay, M Dhureja, R Arthur… - …, 2024 - Springer
Abstract “Path to a good mood lies through the gut.” This statement seems to imply that it has
long been believed that the gut is connected with the brain. Research has shown that eating …

Supplementation with Lactobacillus helveticus NS8 alleviated behavioral, neural, endocrine, and microbiota abnormalities in an endogenous rat model of depression

H Alatan, S Liang, Y Shimodaira, X Wu, X Hu… - Frontiers in …, 2024 - frontiersin.org
Introduction Major depressive disorder is a condition involving microbiota–gut–brain axis
dysfunction. Increasing research aims to improve depression through gut microbiota …

Neuroprotective Effects of Bifidobacterium animalis subsp. lactis NJ241 in a Mouse Model of Parkinson's Disease: Implications for Gut Microbiota and PGC-1α

Y Dong, Y Qi, J Chen, S Han, W Su, X Ma, Y Yu… - Molecular …, 2024 - Springer
Intestinal dysbiosis plays a critical role in the pathogenesis of Parkinson's disease (PD), and
probiotics have emerged as potential modulators of central nervous system function through …

Effects of Lactiplantibacillus plantarum GUANKE on Diphenoxylate-Induced Slow Transit Constipation and Gut Microbiota in Mice

Y Huang, Y Guo, X Li, Y Xiao, Z Wang, L Song, Z Ren - Nutrients, 2023 - mdpi.com
Slow transit constipation (STC) is a prevalent gastrointestinal condition with slow transit, and
some probiotics can effectively relieve constipation, but the exact mechanisms have not …