Cellular and molecular mechanisms of Hedgehog signalling
The Hedgehog signalling pathway has crucial roles in embryonic tissue patterning,
postembryonic tissue regeneration, and cancer, yet aspects of Hedgehog signal …
postembryonic tissue regeneration, and cancer, yet aspects of Hedgehog signal …
Emerging mechanistic understanding of cilia function in cellular signalling
Primary cilia are solitary, immotile sensory organelles present on most cells in the body that
participate broadly in human health, physiology and disease. Cilia generate a unique …
participate broadly in human health, physiology and disease. Cilia generate a unique …
Establishing and regulating the composition of cilia for signal transduction
MV Nachury, DU Mick - Nature reviews Molecular cell biology, 2019 - nature.com
The primary cilium is a hair-like surface-exposed organelle of the eukaryotic cell that
decodes a variety of signals—such as odorants, light and Hedgehog morphogens—by …
decodes a variety of signals—such as odorants, light and Hedgehog morphogens—by …
Seriously cilia: A tiny organelle illuminates evolution, disease, and intercellular communication
C Derderian, GI Canales, JF Reiter - Developmental cell, 2023 - cell.com
The borders between cell and developmental biology, which have always been permeable,
have largely dissolved. One manifestation is the blossoming of cilia biology, with cell and …
have largely dissolved. One manifestation is the blossoming of cilia biology, with cell and …
Smoothened stimulation by membrane sterols drives Hedgehog pathway activity
I Deshpande, J Liang, D Hedeen, KJ Roberts, Y Zhang… - Nature, 2019 - nature.com
Hedgehog signalling is fundamental to embryonic development and postnatal tissue
regeneration. Aberrant postnatal Hedgehog signalling leads to several malignancies …
regeneration. Aberrant postnatal Hedgehog signalling leads to several malignancies …
Cholesterol access in cellular membranes controls Hedgehog signaling
Abstract The Hedgehog (Hh) signaling pathway coordinates cell–cell communication in
development and regeneration. Defects in this pathway underlie diseases ranging from birth …
development and regeneration. Defects in this pathway underlie diseases ranging from birth …
Biochemical mechanisms of vertebrate hedgehog signaling
Signaling pathways that mediate cell-cell communication are essential for collective cell
behaviors in multicellular systems. The hedgehog (HH) pathway, first discovered and …
behaviors in multicellular systems. The hedgehog (HH) pathway, first discovered and …
Structural basis for cholesterol transport-like activity of the hedgehog receptor patched
Hedgehog protein signals mediate tissue patterning and maintenance by binding to and
inactivating their common receptor Patched, a 12-transmembrane protein that otherwise …
inactivating their common receptor Patched, a 12-transmembrane protein that otherwise …
Hedgehog signaling mechanism and role in cancer
J Jiang - Seminars in cancer biology, 2022 - Elsevier
Cell-cell communication through evolutionarily conserved signaling pathways governs
embryonic development and adult tissue homeostasis. Deregulation of these signaling …
embryonic development and adult tissue homeostasis. Deregulation of these signaling …
Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi
The oncoprotein Smoothened (SMO), a G-protein-coupled receptor (GPCR) of the Frizzled-
class (class-F), transduces the Hedgehog signal from the tumour suppressor Patched-1 …
class (class-F), transduces the Hedgehog signal from the tumour suppressor Patched-1 …