Glycosylation is the most complex post-translational modification of proteins. Altered glycans
on the tumor-and host-cell surface and in the tumor microenvironment have been identified …

Pancreatic cancer (PC) is one of the most common causes of cancer-related death. The
underlying mechanism of PC is not completely understood at present. Studies in recent …

Genome-wide association studies (GWAS) with intermediate phenotypes, like changes in
metabolite and protein levels, provide functional evidence to map disease associations and …

Abstract The Tohoku Medical Megabank Organization reports the whole-genome
sequences of 1,070 healthy Japanese individuals and construction of a Japanese …

Despite a growing body of evidence, the role of the gut microbiome in cardiovascular
diseases is still unclear. Here, we present a systems-genome-wide and metagenome-wide …

Abstract Purpose: CA19–9 synthesis is influenced by common variants in the
fucosyltransferase (FUT) enzymes FUT3 and FUT2. We developed a clinical test to detect …

Protein-truncating variants can have profound effects on gene function and are critical for
clinical genome interpretation and generating therapeutic hypotheses, but their relevance to …

Implementing precision medicine for complex diseases such as chronic obstructive lung
disease (COPD) will require extensive use of biomarkers and an in-depth understanding of …

For a long time it has been known that both hypo-and hyperthyroidism are associated with
an increased risk of morbidity and mortality. In recent years, it has also become clear that …

Pancreatic cancer is one of the most aggressive cancers worldwide due to the resistances to
conventional therapies and early metastasis. Recent research has shown that cancer stem …