Virus infection initiates a number of cellular stress responses that modulate gene regulation
and compartmentalization of RNA. Viruses must control host gene expression and the …

Phase transitions that alter the physical state of ribonucleoprotein particles contribute to the
spacial and temporal organization of the densely packed intracellular environment. This …

Fluorescent light-up aptamers (FLAPs) have emerged as valuable tools to visualize RNAs,
but are mostly limited by their poor brightness, low photostability, and high fluorescence …

RNAs directly regulate a vast array of cellular processes, emphasizing the need for robust
approaches to fluorescently label and track RNAs in living cells. Here, we develop an RNA …

ABSTRACT The 5′-to-3′ mRNA degradation machinery localizes to cytoplasmic
processing bodies (P-bodies), which are non-membranous structures found in all …

After viral infection, host cells respond by mounting an anti-viral stress response in order to
create a hostile atmosphere for viral replication, leading to the shut-off of mRNA translation …

Stress granules are dynamic assemblies of proteins and nontranslating RNAs that form
when translation is inhibited in response to diverse stresses. Defects in ubiquitin …

Membraneless biomolecular condensates (BMCs) contribute to the replication of a growing
number of viruses but remain to be functionally characterized. Previously, we demonstrated …

Visualization of RNAs in live cells is critical to understand biology of RNA dynamics and
function in the complex cellular environment. Detection of RNAs with a fluorescent marker …

The use of synthetic messenger ribonucleic acid (mRNA) to express specific proteins is a
highly promising therapeutic and vaccine approach that avoids many safety issues …