Severe ocular surface disease can result in limbal stem cell deficiency (LSCD), a condition
leading to decreased visual acuity, photophobia, and ocular pain. To restore the ocular …

Corneal failure is a highly prevalent cause of blindness. One special cause of corneal failure
occurs due to malfunction or destruction of the limbal stem cell niche, upon which the …

purpose. To construct a full-thickness biological substitute of the rabbit cornea by tissue
engineering. methods. Ten rabbit corneas were surgically excised, and the three main cell …

Purpose To explore the feasibility of bone marrow mesenchymal stem cells (MSCs)
transdifferentiating into corneal epithelial cells in a limbal stem cell deficiency (LSCD) model …

The cornea is a major protective shield of the interior of the eye and represents two thirds of
its refractive power. It is made up of three tissue layers that have different developmental …

Limbal tissues can be cultured on various types of scaffolds to create a sheet of limbal‐
corneal epithelium for research as well as clinical transplantation. An optically clear …

Severe ocular surface disorders can result in deficiency of limbal stem cells that is potentially
associated with chronic inflammation, impaired vision and even blindness. Advanced stem …

Limbal stem cell deficiency (LSCD) is a complex blinding disease of the cornea, which
cannot be treated with conventional corneal transplants. Instead, a stem cell (SC) graft is …

Progress in tissue engineering has led to the development of technologies allowing the
reconstruction of autologous tissues from the patient's own cells. Thus, tissue-engineered …

Reconstruction of large oral mucosa defects is often challenging, since the shortage of
healthy oral mucosa to replace the excised tissues is very common. In this context, tissue …