The evolution of resistance to traditional platinum-based anticancer drugs has compelled
researchers to investigate the cytostatic properties of alternative transition metal-based …

Nitric oxide (NO) is a pleiotropic molecule critical to a number of physiological and
pathological processes. The last decade has witnessed major advances in dissecting NO …

Improvement of ovarian cancer patient outcome requires well-characterized animal models
in which to evaluate novel therapeutics. Xenograft models are frequently used, but with little …

Cobalt is an essential metal that is found in very low abundance in the body and the
environment. Cobalt coordination complexes exhibit interesting redox and magnetic …

Following its successful predecessor, this book covers the fundamentals, delivery routes and
vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters …

Rapidly growing cells show an increased demand for nutrients and vitamins. The objective
of our work is to exploit the supply route of vitamin B12 to deliver new derivatives of this vital …

Importance of the field: Vitamin B12 (B12) is a rare and vital micronutrient for which
mammals have developed a complex and highly efficient dietary uptake system. This uptake …

Background/Aim: Cancer cells have an essential demand for vitamin B12 (cobalamin) to
enable cellular replication. The present pilot study quantified the immunohistochemical …

Interferon-β is a mainstay therapy of demyelinating diseases, but its effects are incomplete in
human multiple sclerosis and several of its animal models. In this study, we demonstrate …

The intrinsic factor (IF) vitamin B12 ileum anchored receptor, cubilin, mediates endocytotic
uptake of the IF complex of vitamin B12 to the blood serum. This receptor was targeted for …