Lost in translation: the valley of death across preclinical and clinical divide–identification of problems and overcoming obstacles

AA Seyhan - Translational Medicine Communications, 2019 - Springer
A rift that has opened up between basic research (bench) and clinical research and patients
(bed) who need their new treatments, diagnostics and prevention, and this rift is widening …

Are innovation and new technologies in precision medicine paving a new era in patients centric care?

AA Seyhan, C Carini - Journal of translational medicine, 2019 - Springer
Healthcare is undergoing a transformation, and it is imperative to leverage new technologies
to generate new data and support the advent of precision medicine (PM). Recent scientific …

Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study

AA Seyhan, YO Nunez Lopez, H Xie, F Yi, C Mathews… - Scientific reports, 2016 - nature.com
The clinical presentation of diabetes sometimes overlaps, contributing to ambiguity in the
diagnosis. Thus, circulating pancreatic islet-enriched microRNAs (miRNAs) might be useful …

Altered levels of circulating cytokines and microRNAs in lean and obese individuals with prediabetes and type 2 diabetes

YON Lopez, G Garufi, AA Seyhan - Molecular biosystems, 2017 - pubs.rsc.org
Today obesity and type 2 diabetes (T2D) have both reached epidemic proportions.
However, our current understanding of the primary mechanisms leading to these diseases is …

Circulating microRNAs as potential biomarkers in pancreatic cancer—advances and challenges

AA Seyhan - International journal of molecular sciences, 2023 - mdpi.com
There is an urgent unmet need for robust and reliable biomarkers for early diagnosis,
prognosis, and prediction of response to specific treatments of many aggressive and deadly …

Advances in liquid biopsy technology and implications for pancreatic cancer

AG Raufi, MS May, MJ Hadfield, AA Seyhan… - International journal of …, 2023 - mdpi.com
Pancreatic cancer is a highly aggressive malignancy with a climbing incidence. The majority
of cases are detected late, with incurable locally advanced or metastatic disease. Even in …

Trials and tribulations of MicroRNA therapeutics

AA Seyhan - International Journal of Molecular Sciences, 2024 - mdpi.com
The discovery of the link between microRNAs (miRNAs) and a myriad of human diseases,
particularly various cancer types, has generated significant interest in exploring their …

CDKN2B-AS1 as a novel therapeutic target in cancer: Mechanism and clinical perspective

A Hjazi, E Ghaffar, W Asghar, HA Khalaf… - Biochemical …, 2023 - Elsevier
Long non-coding RNAs (lncRNA) have been identified as essential components having
considerable modulatory impacts on biological activities through altering gene transcription …

Gastric bypass surgery with exercise alters plasma microRNAs that predict improvements in cardiometabolic risk

YO Nunez Lopez, PM Coen, BH Goodpaster… - International Journal of …, 2017 - nature.com
Results: Mirroring results in the parent trial, both groups experienced significant weight loss
and improvements in cardiometabolic risk. In the CON group, weight loss significantly …

High-throughput and sensitive fluorimetric strategy for microRNAs in blood using wettable microwells array and silver nanoclusters with red fluorescence enhanced by …

L Feng, M Liu, H Liu, C Fan, Y Cai, L Chen… - … applied materials & …, 2018 - ACS Publications
A high-throughput and sensitive fluorimetric analysis method has been developed with
wettable microwells array for probing short-chain microRNAs (miRNAs) in blood using silver …