Obesity is a complex disease that is regulated by both central and peripheral mechanisms.
New medicines for the treatment and prevention of obesity will need to overcome the …

Aging is associated with dysregulation of glucose and lipid metabolism. Various factors that
contribute to the dysregulation include both modifiable (eg obesity, insulin resistance) and …

Having direct access to brain vasculature, astrocytes can take up available blood nutrients
and metabolize them to fulfil their own energy needs and deliver metabolic intermediates to …

2014-11-12 Assigned to IMMATICS BIOTECHNOLOGIES GMBH reassignment IMMATICS
BIOTECHNOLOGIES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …

Fatty acid synthesis in the central nervous system is implicated in the control of food intake
and energy expenditure. An intermediate in this pathway, malonyl-CoA, mediates these …

Long-chain-length hydrophobic acyl residues play a vital role in a multitude of essential
biological structures and processes. They build the inner hydrophobic layers of biological …

Vinorine synthase is an acetyltransferase that occupies a central role in the biosynthesis of
the antiarrhythmic monoterpenoid indole alkaloid ajmaline in the plant Rauvolfia. Vinorine …

Molting is a critical developmental process for crustaceans, yet the underlying molecular
mechanism is unknown. In this study, we used RNA-Seq to investigate transcriptomic …

The need for new antibiotic therapies is acute and growing in large part because of the
emergence of drug-resistant pathogens. A vast number of resistance determinants are …

Abstract Sterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-
transmembrane enzyme that belongs to the membrane-bound O-acyltransferase (MBOAT) …