P2X7 receptor and purinergic signaling: orchestrating mitochondrial dysfunction in neurodegenerative diseases

AS Zelentsova, AV Deykin, VO Soldatov, AA Ulezko… - Eneuro, 2022 - eneuro.org
Mitochondrial dysfunction is one of the basic hallmarks of cellular pathology in
neurodegenerative diseases. Since the metabolic activity of neurons is highly dependent on …

High levels of extracellular ATP lead to different inflammatory responses in COVID-19 patients according to the severity

GB da Silva, D Manica, AP da Silva… - Journal of Molecular …, 2022 - Springer
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
significantly impacted the world and has driven many researchers into the pathophysiology …

Cytokine storm in human monkeypox: A possible involvement of purinergic signaling

GB da Silva, G de Carvalho Braga, JLB Simões… - Cytokine, 2024 - Elsevier
Some evidence has indicated that monkeypox can induce a cytokine storm. Purinergic
signaling is a cell pathway related to the cytokine storm. However, the precise mechanisms …

Curcumin administration mitigates cyclophosphamide-induced oxidative damage and restores alteration of enzymes associated with cognitive function in rats' brain

SF Akomolafe, TA Olasehinde, SI Oyeleye… - Neurotoxicity …, 2020 - Springer
The use of chemotherapeutic drugs is associated with oxidative damage, cognitive
dysfunction, and brain damage. This study sought to investigate the neuroprotective effect of …

Oxidative testicular injury: effect of l-leucine on redox, cholinergic and purinergic dysfunctions, and dysregulated metabolic pathways

OL Erukainure, O Atolani, P Banerjee, R Abel, OJ Pooe… - Amino Acids, 2021 - Springer
The antioxidant and anti-proinflammatory activities of l-leucine were investigated on
oxidative testicular injury, ex vivo. In vitro analysis revealed l-leucine to be a potent …

Cannabis sativa L. (var. indica) Exhibits Hepatoprotective Effects by Modulating Hepatic Lipid Profile and Mitigating Gluconeogenesis and Cholinergic Dysfunction in …

OL Erukainure, MG Matsabisa, VF Salau… - Frontiers in …, 2021 - frontiersin.org
Cannabis sativa L. is a crop utilized globally for recreational, therapeutic, and religious
purposes. Although considered as an illicit drug in most countries, C. sativa until recently …

Ferulic acid mitigates diabetic cardiomyopathy via modulation of metabolic abnormalities in cardiac tissues of diabetic rats

VF Salau, OL Erukainure, KA Olofinsan… - Fundamental & …, 2023 - Wiley Online Library
Cardiovascular abnormalities have been reported as a major contributor of diabetic
mortality. The protective effect of ferulic acid on diabetic cardiomyopathy in fructose …

Purinergic signaling and tumor microenvironment in cervical cancer

MS Pfaffenzeller, MLM Franciosi, AM Cardoso - Purinergic signalling, 2020 - Springer
Cervical cancer is the fourth most common type of cancer incidence in the world female
population, and it has become a public health problem worldwide. Several factors are …

Naringin attenuates Bisphenol-A mediated neurotoxicity in hypertensive rats by abrogation of cerebral nucleotide depletion, oxidative damage and neuroinflammation

JK Akintunde, TE Akintola, GO Adenuga, ZA Odugbemi… - Neurotoxicology, 2020 - Elsevier
We examined whether active fruit naringin can reduce the risk of BPA-mediated
neurotoxicity in L-NAME induced hypertensive rats and whether the modulation could be …

Modulatory effect of ursolic acid on neurodegenerative activities in oxidative brain injury: An ex vivo study

VF Salau, OL Erukainure, G Ayeni… - Journal of Food …, 2021 - Wiley Online Library
Natural products‐based antioxidants have been well reported for their therapeutic benefits
in the treatment and management of neurodegenerative diseases. The neuroprotective …