Cisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is
limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can …

Cisplatin is a clinically advanced and highly effective anticancer drug used in the treatment
of a wide variety of malignancies, such as head and neck, lung, testis, ovary, breast cancer …

Acute kidney injury (AKI) is a global health challenge of vast proportions, as approx. 13.3%
of people worldwide are affected annually. The pathophysiology of AKI is very complex, but …

Cisplatin is a widely used chemotherapeutic agent used to treat solid tumours, such as
ovarian, head and neck, and testicular germ cell. A known complication of cisplatin …

Background Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective
chemotherapeutic agents. However, its clinical use is limited due to the severe side effects …

Cisplatin is a highly effective antitumor agent whose clinical application is limited by the
inherent nephrotoxicity. The current measures of nephroprotection used in patients receiving …

Following the serendipitous discovery of the anticancer activity of cisplatin over 50 years
ago, a deep understanding of the chemical and biochemical transformations giving rise to its …

Journal of Clinical Oncology recently featured the dramatic changes that took place within
the last 50 years resulting in transforming malignant germ cell testicular tumors from highly …

Cisplatin (cis-diamminedichloroplatinum (II)) is the oldest known chemotherapeutic agent.
Since the identification of its anti-tumour activity, it earned a remarkable place as a treatment …

The field of medicinal inorganic chemistry has grown consistently during the past 50 years;
however, metal-containing coordination compounds represent only a minor proportion of …