Structure-based drug design (SBDD) heavily relies on the production of high-resolution (<
2Å) three-dimensional (3D) structures of the drug target in the presence or absence of the …

During metaphase, in response to improper kinetochore‐microtubule attachments, the
spindle assembly checkpoint (SAC) activates the mitotic checkpoint complex (MCC), an …

The structural and functional details of transmembrane proteins are vastly underexplored,
mostly due to experimental difficulties regarding their solubility and stability. Currently, the …

Deoxyhypusine synthase (DHS) is a transferase enabling the formation of deoxyhypusine,
which is the first, rate-limiting step of a unique post-translational modification: hypusination …

Broad-specificity glycoside hydrolases (GHs) contribute to plant biomass hydrolysis by
degrading a diverse range of polysaccharides, making them useful catalysts for renewable …

Kinetochores are large multi-subunit complexes that attach centromeric chromatin to
microtubules of the mitotic spindle, enabling sister chromatid segregation in mitosis. The …

When high quality crystals are obtained that diffract X-rays, the crystal structure may be
solved at near atomic resolution. The conditions to crystallize proteins, DNAs, RNAs, and …

Co-crystallization of a 2 kDa tether-free sulfonated foldamer and the 13 kDa lysine-rich
cytochrome c yielded a remarkable biohybrid assembly with chiral resolution of the foldamer …

High-quality crystals are essential to ensure high-resolution structural information. Protein
crystals are controlled by many factors, such as pH, temperature, and the ion concentration …

Interactions between a protein and a peptide motif of its protein partner are prevalent in
nature. Often, a protein also has multiple interaction partners. X-ray protein crystallography …