Itch is a unique sensory experience that is encoded by genetically distinguishable neurons
both in the peripheral nervous system (PNS) and central nervous system (CNS) to elicit a …

Cutaneous neurogenic inflammation (CNI) is inflammation that is induced (or enhanced) in
the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations …

Atopic dermatitis (AD) is a common, chronic-relapsing inflammatory skin disease with
significant disease burden. Genetic and environmental trigger factors contribute to AD …

Nociception is an important physiological process that detects harmful signals and results in
pain perception. In this review, we discuss important experimental evidence involving some …

Itch is a topic to which everyone can relate. The physiological roles of itch are increasingly
understood and appreciated. The pathophysiological consequences of itch impact quality of …

Itch is one of the most primal sensations, being both ubiquitous and important for the well-
being of animals. For more than a century, a desire to understand how itch is encoded by the …

Although the medical definition of itch has been in existence for 360 years, only in the last 20
years have we begun to understand the basic mechanisms that underlie this unique …

Atopic dermatitis (AD) is a multifaceted, chronic relapsing inflammatory skin disease that
affects people of all ages. It is characterized by chronic eczema, constant pruritus, and …

Ion channels of the Transient Receptor Potential (TRP) family mediate the influx of
monovalent and/or divalent cations into cells in response to a host of chemical or physical …

Transient Receptor Potential (TRP) channels are a family of ion channels whose members
are distributed among all kinds of animals, from invertebrates to vertebrates. The importance …