Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …

In the cardio-oncology population, drug interactions are of particular importance given the
complex pharmacological profile, narrow therapeutic index, and inherent risk of therapies …

Background Anticoagulation in patients with malignancy and atrial fibrillation is challenging
because of enhanced risks for thrombosis and bleeding and the frequent need for invasive …

Introduction: Sulfonamide compounds are significant class of synthetic bacteriostatic
antibiotics still which used today for the therapy of bacterial infections and those caused by …

Cytochrome (CYP) 450 isoenzymes are the basic enzymes involved in Phase I
biotransformation. The most important role in biotransformation belongs to CYP3A4 …

We report the synthesis and photochemical and biological characterization of the first
selective and potent metal-based inhibitors of cytochrome P450 3A4 (CYP3A4), the major …

Cardiotoxic effects of chemotherapy and targeted drugs are ubiquitous and challenging in
the field of oncology therapeutics. The broad spectrum of toxicities ranging from ischemic …

Anti-angiogenic treatment is an important option that has changed the therapeutic
landscape in various tumors, particularly in patients affected by renal cell carcinoma (RCC) …

Disruption of epigenetic mechanisms has been intimately linked to the etiology of human
cancer. Understanding how these epigenetic mechanisms (including DNA methylation …

Inhibition and induction of drug-metabolizing enzymes are the most frequent and dangerous
drug-drug interactions. They are an important cause of serious adverse events that have …