Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

In most cases, protein aggregation stems from the establishment of non-native
intermolecular contacts. The formation of insoluble protein aggregates is associated with …

Therapeutic monoclonal antibodies and their derivatives are key components of clinical
pipelines in the global biopharmaceutical industry. The availability of large datasets of …

Protein aggregation is a widespread phenomenon with important implications in many
scientific areas. Although amyloid formation is typically considered as detrimental, functional …

Recombinant proteins are the mainstay of biopharmaceuticals. A key challenge in the
manufacturing and formulation of protein biologic products is the tendency for the active …

Protein aggregation is a hallmark of a growing number of human disorders and constitutes a
major bottleneck in the manufacturing of therapeutic proteins. Therefore, there is a strong …

Protein pharmaceuticals have become a significant class of marketed drug products and are
expected to grow steadily over the next decade. Development of a commercial protein …

Protein aggregation has been associated with aging and different pathologies and
represents a bottleneck in the industrial production of biotherapeutics. Numerous past …

Antibody-based biotherapeutics have emerged as a successful class of pharmaceuticals
despite significant challenges and risks to their discovery and development. This review …

Therapeutic antibody technology heavily dominates the biologics market and continues to
present as a significant industrial interest in developing novel and improved antibody …