RNA modifications: importance in immune cell biology and related diseases

L Cui, R Ma, J Cai, C Guo, Z Chen, L Yao… - Signal transduction and …, 2022 - nature.com
RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …

The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities

P Nombela, B Miguel-López, S Blanco - Molecular cancer, 2021 - Springer
RNA modifications have recently emerged as critical posttranscriptional regulators of gene
expression programmes. Significant advances have been made in understanding the …

Dynamic transcriptomic m5C and its regulatory role in RNA processing

YS Chen, WL Yang, YL Zhao… - Wiley Interdisciplinary …, 2021 - Wiley Online Library
Abstract RNA 5‐methylcytosine (m5C) is a prevalent RNA modification in multiple RNA
species, including messenger RNAs (mRNAs), transfer RNAs (tRNAs), ribosomal RNAs …

5-methylcytosine RNA methyltransferases and their potential roles in cancer

M Li, Z Tao, Y Zhao, L Li, J Zheng, Z Li… - Journal of translational …, 2022 - Springer
Abstract In recent years, 5-methylcytosine (m5C) RNA modification has emerged as a key
player in regulating RNA metabolism and function through coding as well as non-coding …

Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine

C Xue, Q Chu, Q Zheng, S Jiang, Z Bao, Y Su… - Signal transduction and …, 2022 - nature.com
Cancer is one of the major diseases threatening human life and health worldwide.
Epigenetic modification refers to heritable changes in the genetic material without any …

[HTML][HTML] The role of RNA m5C modification in cancer metastasis

Q Zhang, F Liu, W Chen, H Miao, H Liang… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Epigenetic modification plays a crucial regulatory role in the biological processes of
eukaryotic cells. The recent characterization of DNA and RNA methylation is still ongoing …

Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer

V Ortiz-Barahona, M Soler, V Davalos… - Molecular Cancer, 2023 - Springer
Background RNA modifications are important regulators of transcript activity and an
increasingly emerging body of data suggests that the epitranscriptome and its associated …

Advances in targeting RNA modifications for anticancer therapy

MM Pomaville, C He - Trends in Cancer, 2023 - cell.com
Numerous strategies are employed by cancer cells to control gene expression and facilitate
tumorigenesis. In the study of epitranscriptomics, a diverse set of modifications to RNA …

Epigenetic reprogramming in cancer: From diagnosis to treatment

PMS Costa, SLA Sales, DP Pinheiro… - Frontiers in cell and …, 2023 - frontiersin.org
Disruption of the epigenetic program of gene expression is a hallmark of cancer that initiates
and propagates tumorigenesis. Altered DNA methylation, histone modifications and ncRNAs …

NSUN2-mediated m5C modification of HBV RNA positively regulates HBV replication

J Feng, T Xu, M He, J Li, P Yao, C Ma, S Yang… - Plos …, 2023 - journals.plos.org
Chronic hepatitis B virus (HBV) infection is a major cause of liver cirrhosis and liver cancer,
despite strong prevention and treatment efforts. The study of the epigenetic modification of …