[HTML][HTML] Pharmacological modulation of vascular ageing: a review from VascAgeNet

L Roth, S Dogan, BG Tuna, T Aranyi, S Benitez… - Ageing research …, 2023 - Elsevier
Vascular ageing, characterized by structural and functional changes in blood vessels of
which arterial stiffness and endothelial dysfunction are key components, is associated with …

Measuring arterial stiffness in animal experimental studies

M Butlin, I Tan, B Spronck, AP Avolio - … , Thrombosis, and Vascular …, 2020 - Am Heart Assoc
The arterial wall is a composite material of elastin, collagen, and extracellular matrix with
acutely modifiable material properties through the action of smooth muscle cells. Therefore …

Role of smooth muscle activation in the static and dynamic mechanical characterization of human aortas

G Franchini, ID Breslavsky… - Proceedings of the …, 2022 - National Acad Sciences
Experimental data and a suitable material model for human aortas with smooth muscle
activation are not available in the literature despite the need for developing advanced grafts; …

Excessive adventitial stress drives inflammation-mediated fibrosis in hypertensive aortic remodelling in mice

B Spronck, M Latorre, M Wang… - Journal of the …, 2021 - royalsocietypublishing.org
Hypertension induces significant aortic remodelling, often adaptive but sometimes not. To
identify immuno-mechanical mechanisms responsible for differential remodelling, we …

Developmental origins of mechanical homeostasis in the aorta

SI Murtada, Y Kawamura, G Li… - Developmental …, 2021 - Wiley Online Library
Background Mechanical homeostasis promotes proper aortic structure and function.
Pathological conditions may arise, in part, from compromised or lost homeostasis. There is …

Arterial stiffness: different metrics, different meanings

B Spronck, JD Humphrey - Journal of …, 2019 - asmedigitalcollection.asme.org
Findings from basic science and clinical studies agree that arterial stiffness is fundamental to
both the mechanobiology and the biomechanics that dictate vascular health and disease …

Smooth muscle contribution to vaginal viscoelastic response

GL Clark-Patterson, LM Buchanan, BO Ogola… - Journal of the …, 2023 - Elsevier
Smooth muscle cells contribute to the mechanical function of various soft tissues, however,
their contribution to the viscoelastic response when subjected to multiaxial loading remains …

[图书][B] Vascular Biomechanics

TC Gasser - 2021 - Springer
The development of the vascular system was a critical step in the evolution of species. It
allowed organisms to meet the growing metabolic demands and opened the door for the …

Aortic remodeling is modest and sex-independent in mice when hypertension is superimposed on aging

B Spronck, J Ferruzzi, C Bellini, AW Caulk… - Journal of …, 2020 - journals.lww.com
Objectives: Increased central artery stiffness associates with cardiovascular disease. Among
other factors, hypertension and aging are strong contributors to central artery stiffening, yet it …

Maladaptive aortic remodeling in hypertension associates with dysfunctional smooth muscle contractility

A Korneva, JD Humphrey - American Journal of Physiology …, 2019 - journals.physiology.org
Intramural cells are responsible for establishing, maintaining, and restoring the functional
capability and structural integrity of the aortic wall. In response to hypertensive loading …