The arterial wall is a composite material of elastin, collagen, and extracellular matrix with acutely modifiable material properties through the action of smooth muscle cells. Therefore …
Experimental data and a suitable material model for human aortas with smooth muscle activation are not available in the literature despite the need for developing advanced grafts; …
B Spronck, M Latorre, M Wang… - Journal of the …, 2021 - royalsocietypublishing.org
Hypertension induces significant aortic remodelling, often adaptive but sometimes not. To identify immuno-mechanical mechanisms responsible for differential remodelling, we …
Background Mechanical homeostasis promotes proper aortic structure and function. Pathological conditions may arise, in part, from compromised or lost homeostasis. There is …
B Spronck, JD Humphrey - Journal of …, 2019 - asmedigitalcollection.asme.org
Findings from basic science and clinical studies agree that arterial stiffness is fundamental to both the mechanobiology and the biomechanics that dictate vascular health and disease …
Smooth muscle cells contribute to the mechanical function of various soft tissues, however, their contribution to the viscoelastic response when subjected to multiaxial loading remains …
The development of the vascular system was a critical step in the evolution of species. It allowed organisms to meet the growing metabolic demands and opened the door for the …
Objectives: Increased central artery stiffness associates with cardiovascular disease. Among other factors, hypertension and aging are strong contributors to central artery stiffening, yet it …
A Korneva, JD Humphrey - American Journal of Physiology …, 2019 - journals.physiology.org
Intramural cells are responsible for establishing, maintaining, and restoring the functional capability and structural integrity of the aortic wall. In response to hypertensive loading …